PCNT and NIPBL

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PCNT	NIPBL
Description		pericentrin	NIPBL cohesin loading factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Membrane Centriolar Satellite	Chromatin Nucleus Nucleoplasm Chromosome Cytosol Integrator Complex SMC Loading Complex Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding Mediator Complex Binding Histone Deacetylase Binding Cohesin Loader Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Nucleation Mitotic Spindle Organization Signal Transduction Cilium Assembly Positive Regulation Of Intracellular Protein Transport	Mitotic Sister Chromatid Segregation Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Mitotic Sister Chromatid Cohesion Brain Development Heart Development Sensory Perception Of Sound Intracellular Protein Localization Regulation Of Gene Expression Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gallbladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Cohesin Loading onto Chromatin
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome	Cornelia de Lange syndrome (CdLS)
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) S100 calcium-binding protein levels ( 33227023) Treatment resistant depression ( 30468137)	Height ( 25282103 28552196 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		55 interacting genes: AKAP6 AKAP9 ANKRD24 ARHGAP21 CALM1 CALM2 CCP110 CEP55 CEP85L CYTH1 DISC1 DMXL2 DNM1 DNM2 DNM3 DST EIF4G3 FEZ1 HMOX2 HUWE1 KALRN KIF1A KIF5C MACF1 MADD MAP1LC3A MAP1LC3B MRFAP1 MYT1L NECAB1 NIPBL ODF2L PARVB PCM1 PNISR RPRD1A RRBP1 RTRAF SEPTIN7 SHTN1 SPTAN1 SPTBN1 SPTBN2 SRGAP2 ST18 SYNE1 TP53BP1 TRAF3IP1 TUBG1 TUBGCP2 TUBGCP3 UTRN YWHAH YWHAZ YY1AP1	11 interacting genes: CBX5 CDK6 DBN1 DSCR9 HINFP MAP1LC3C PCNA PCNT PRSS23 SP100 SUMO2
Entrez ID		5116	25836
HPRD ID		05804	10560
Ensembl ID		ENSG00000160299	ENSG00000164190
Uniprot IDs		O95613	A0A590UJS4 Q6KC79
PDB IDs			6WG3 6WGE 7W1M
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cell Projection Organelle Organization Cytoplasm Centrosome Microtubule Binding Cell Projection Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Microtubule-based Process Actin Binding Centriole Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Organization Spectrin Identical Protein Binding Microtubule Nucleation Gamma-tubulin Complex Cell Projection Assembly Cellular Component Assembly Transmembrane Transporter Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Scission Microtubule Minus-end Binding Ciliary Basal Body Microtubule Organizing Center Structural Constituent Of Cytoskeleton Transport Along Microtubule Microtubule Cytoskeleton Cytosol Plasma Membrane Bounded Cell Projection Assembly Organelle Localization Sarcomere Establishment Of Organelle Localization Cell Leading Edge Pericentriolar Material Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Actin Filament Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Polar Microtubule Actin Filament-based Process Microtubule-based Transport Cadherin Binding Regulation Of Cellular Component Organization Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity	DNA Damage Response Generation Of Neurons PML Body Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Postsynaptic Cytosol Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Maintenance Of Protein Location In Cell PCNA Complex Replisome Negative Regulation Of DNA-templated Transcription G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Cell Communication By Chemical Coupling Maintenance Of Protein Location Maintenance Of Location In Cell Maintenance Of Location PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neurogenesis Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of Fas Signaling Pathway
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