COPB2 and NDRG1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		COPB2	NDRG1
Description		coat protein complex I subunit beta 2	N-myc downstream regulated 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Kawasaki disease ( 22446961) Male-pattern baldness ( 29146897)	Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		16 interacting genes: ARCN1 COPA CRYAA MCPH1 MFHAS1 MSRA NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L SUMO2 TMED10 WBP2 WEE2-AS1	71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		9276	10397
HPRD ID		06103	05586
Ensembl ID		ENSG00000184432	ENSG00000104419
Uniprot IDs		P35606	Q8N959 Q92597
PDB IDs		8D30 8D41	6ZMM
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Negative Regulation Of Glycine Import Across Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI-coated Vesicle Membrane COPI Vesicle Coat Negative Regulation Of Amino Acid Transport Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Ethanol Negative Regulation Of Transmembrane Transport Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth G-protein Alpha-subunit Binding Response To Amphetamine Negative Regulation Of Organ Growth Negative Regulation Of Transport Positive Regulation Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Amine Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Secretion Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cerebellar Purkinje Cell Layer Maturation NF-kappaB P50/p65 Complex Response To Alcohol Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Golgi Vesicle Transport Regulation Of Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Golgi Membrane Body Fluid Secretion Response To Hypoxia Positive Regulation Of Signal Transduction Regulation Of Amine Transport Response To Decreased Oxygen Levels Positive Regulation Of Hyaluronan Biosynthetic Process	Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression
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