COPB2 and RGS2

Number of citations of the paper that reports this interaction (PMID 10982407)
7

Data Source:
HPRD (two hybrid, in vitro)

		COPB2	RGS2
Gene Name		coatomer protein complex, subunit beta 2 (beta prime)	regulator of G-protein signaling 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol COPI Vesicle Coat	Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Structural Molecule Activity	GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Membrane Organization	Regulation Of Translation Cell Cycle Spermatogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Smooth Muscle Positive Regulation Of Cardiac Muscle Contraction Regulation Of Adrenergic Receptor Signaling Pathway
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961)
Protein-Protein Interactions		10 interactors: ARCN1 COPA COPE NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L TMED10	58 interactors: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CHD3 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KIAA1377 KLK8 LIG1 LRFN1 METTL18 MON1A MTUS2 NINL NIPSNAP1 PARK2 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		9276	5997
HPRD ID		06103	02917
Ensembl ID		ENSG00000184432	ENSG00000116741
Uniprot IDs		P35606	P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Membrane Budding Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Membrane Organization Organelle Localization Response To Alkaloid Vesicle-mediated Transport Intracellular Transport Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Glucuronidation Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Establishment Of Localization In Cell Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels ER To Golgi Vesicle-mediated Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Positive Regulation Of Protein Polymerization Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of Innate Immune Response Cellular Localization Regulation Of Carbohydrate Metabolic Process Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Protein Transport Negative Regulation Of MAPK Cascade	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Wounding Blood Coagulation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Hemostasis Wound Healing Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Nervous System Development Regulation Of Cyclase Activity Activation Of Adenylate Cyclase Activity Signaling Response To Stress Neurotrophin Signaling Pathway Cell Communication Regulation Of Phosphorylation Dopamine Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Developmental Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Stimulus Regulation Of Muscle Contraction Anatomical Structure Development Regulation Of CAMP Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Hydrolase Activity Cell Activation Membrane Organization Regulation Of CAMP Metabolic Process Regulation Of Protein Phosphorylation System Development Positive Regulation Of Lyase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Budding Adrenergic Receptor Signaling Pathway
Tagcloud ?		addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation differentially dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Difference) ?		addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish	3t3 adipocyte already arrested beginning cloned clones earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Intersection) ?		differentially