COPB2 and PRKCE

Number of citations of the paper that reports this interaction (PubMedID 9360998)
0

Data Source:
HPRD (in vitro)

		COPB2	PRKCE
Description		coat protein complex I subunit beta 2	protein kinase C epsilon
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Structural Molecule Activity Protein Binding	Nucleotide Binding Actin Monomer Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	MAPK Cascade Macrophage Activation Involved In Immune Response Immune System Process Apoptotic Process Cell Adhesion Signal Transduction Toxin Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Regulation Of Metal Ion Transport Peptidyl-serine Phosphorylation Regulation Of Lipid Metabolic Process Insulin Secretion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Cell-substrate Adhesion Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Positive Regulation Of Superoxide Anion Generation Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Xenobiotic Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Establishment Of Localization In Cell Synaptic Transmission, GABAergic Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events
Drugs			Tamoxifen Staurosporine Dequalinium KAI-1455 Benzoyl peroxide Bryostatin 1 Fostamatinib
Diseases
GWAS		Kawasaki disease ( 22446961) Male-pattern baldness ( 29146897)	Appendicular lean mass ( 33097823) Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 33020668 29212778) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30578418 28135244) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 29403010 19862010 27863252 28453575 28017375) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 19862010 28453575 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) High light scatter reticulocyte count ( 27863252 32888494) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monocyte count ( 32888494) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 27841878 30578418 28135244) Red blood cell count ( 32888494 20139978 29403010 28017375 27863252) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ARCN1 COPA CRYAA MCPH1 MFHAS1 MSRA NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L SUMO2 TMED10 WBP2 WEE2-AS1	59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1
Entrez ID		9276	5581
HPRD ID		06103	01500
Ensembl ID		ENSG00000184432	ENSG00000171132
Uniprot IDs		P35606	L7RTI5 Q02156
PDB IDs		8D30 8D41	2WH0 5LIH
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Negative Regulation Of Glycine Import Across Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI-coated Vesicle Membrane COPI Vesicle Coat Negative Regulation Of Amino Acid Transport Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Ethanol Negative Regulation Of Transmembrane Transport Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth G-protein Alpha-subunit Binding Response To Amphetamine Negative Regulation Of Organ Growth Negative Regulation Of Transport Positive Regulation Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Amine Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Secretion Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cerebellar Purkinje Cell Layer Maturation NF-kappaB P50/p65 Complex Response To Alcohol Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Golgi Vesicle Transport Regulation Of Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Golgi Membrane Body Fluid Secretion Response To Hypoxia Positive Regulation Of Signal Transduction Regulation Of Amine Transport Response To Decreased Oxygen Levels Positive Regulation Of Hyaluronan Biosynthetic Process	Regulation Of Biological Quality Intracellular Signaling Cassette Focal Adhesion Cytoplasm Regulation Of Anatomical Structure Morphogenesis Phosphorylation Plasma Membrane Regulation Of Developmental Process Protein Phosphorylation Regulation Of Multicellular Organismal Process Kinase Activity Membrane Raft Regulation Of Membrane Potential Intracellular Signal Transduction ATP Binding Nucleotide Binding Regulation Of Transport Protein Kinase Activity Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phospholipase Binding ERBB Signaling Pathway Response To Growth Factor Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Regulation Of Cellular Localization Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phospholipase Activator Activity Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion MAPK Cascade Cell-cell Signaling Chemical Synaptic Transmission Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Apoptotic Process Scaffold Protein Binding Positive Regulation Of Signal Transduction
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