COPB2 and TMED10

Number of citations of the paper that reports this interaction (PubMedID 9751720)
38

Data Source:
BioGRID (pull down)

		COPB2	TMED10
Description		coat protein complex I subunit beta 2	transmembrane p24 trafficking protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Vesicle-mediated Transport Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961) Male-pattern baldness ( 29146897)	Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ARCN1 COPA CRYAA MCPH1 MFHAS1 MSRA NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L SUMO2 TMED10 WBP2 WEE2-AS1	20 interacting genes: APH1A ARCN1 ARF1 CDC42 CEBPA COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 NCSTN NPSR1 PSENEN SEC23B SLC13A1 TMED2
Entrez ID		9276	10972
HPRD ID		06103	12013
Ensembl ID		ENSG00000184432	ENSG00000170348
Uniprot IDs		P35606	A0A024R6I3 P49755
PDB IDs		8D30 8D41
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Negative Regulation Of Glycine Import Across Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI-coated Vesicle Membrane COPI Vesicle Coat Negative Regulation Of Amino Acid Transport Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Ethanol Negative Regulation Of Transmembrane Transport Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth G-protein Alpha-subunit Binding Response To Amphetamine Negative Regulation Of Organ Growth Negative Regulation Of Transport Positive Regulation Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Amine Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Secretion Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cerebellar Purkinje Cell Layer Maturation NF-kappaB P50/p65 Complex Response To Alcohol Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Golgi Vesicle Transport Regulation Of Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Golgi Membrane Body Fluid Secretion Response To Hypoxia Positive Regulation Of Signal Transduction Regulation Of Amine Transport Response To Decreased Oxygen Levels Positive Regulation Of Hyaluronan Biosynthetic Process	COPI-coated Vesicle Membrane COPI Vesicle Coat Golgi Membrane Transport Vesicle COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Membrane Coat Endoplasmic Reticulum Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Transport Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Protein Transport Gamma-secretase Complex Structural Molecule Activity Notch Receptor Processing Amyloid-beta Formation Intracellular Protein Localization Membrane Protein Intracellular Domain Proteolysis Golgi Localization Amyloid Precursor Protein Catabolic Process Endopeptidase Activator Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Membrane Membrane Protein Proteolysis Notch Signaling Pathway Establishment Of Golgi Localization Endoplasmic Reticulum Golgi Cisterna Membrane Protein Localization To Axon Organelle Transport Along Microtubule Embryonic Placenta Development Protein Secretion Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Presynaptic Membrane Vesicle Cargo Loading Dendritic Spine Organization Mitotic Cleavage Furrow Ingression RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
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