COPB2 and TMED10

Number of citations of the paper that reports this interaction (PMID 9751720)
22

Data Source:
BioGRID (pull down)

		COPB2	TMED10
Gene Name		coatomer protein complex, subunit beta 2 (beta prime)	transmembrane emp24-like trafficking protein 10 (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol COPI Vesicle Coat	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome Gamma-secretase Complex
	Molecular Function	Structural Molecule Activity	Protein Binding Syntaxin Binding Protein Complex Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Membrane Organization	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Secretory Pathway Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Protein Oligomerization Regulation Of Beta-amyloid Formation
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961)	Height ( 19343178)
Protein-Protein Interactions		10 interactors: ARCN1 COPA COPE NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L TMED10	15 interactors: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPZ1 DHODH GORASP2 NCSTN PSENEN SEC23B TMED2
Entrez ID		9276	10972
HPRD ID		06103	12013
Ensembl ID		ENSG00000184432	ENSG00000170348
Uniprot IDs		P35606	B4DL12 P49755
PDB IDs
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Membrane Budding Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Membrane Organization Organelle Localization Response To Alkaloid Vesicle-mediated Transport Intracellular Transport Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Glucuronidation Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Establishment Of Localization In Cell Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels ER To Golgi Vesicle-mediated Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Positive Regulation Of Protein Polymerization Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of Innate Immune Response Cellular Localization Regulation Of Carbohydrate Metabolic Process Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Protein Transport Negative Regulation Of MAPK Cascade	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Transport Protein Localization Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Amyloid Precursor Protein Catabolic Process Membrane Protein Intracellular Domain Proteolysis Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Cellular Localization Notch Receptor Processing Cellular Protein Localization Membrane Protein Proteolysis Organelle Organization Transport Ephrin Receptor Signaling Pathway ER To Golgi Vesicle-mediated Transport Notch Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cerebellar Purkinje Cell Layer Maturation Apoptotic Signaling Pathway Axon Guidance Cerebellum Maturation 'de Novo' UMP Biosynthetic Process Body Fluid Secretion Axonogenesis Establishment Of Golgi Localization
Tagcloud ?		addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation differentially dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Difference) ?		addiction axonogenesis bnip4 camk1gammab candidates classes cns dao dendritogenesis deregulation differentially dopaminergic glutamatergic grb2 great grik indicative magi1b morphine mu neurotransmission opioid otpb patterning serotonergic sox19b whose wls zebrafish	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Intersection) ?