COPB2 and WBP2

Number of citations of the paper that reports this interaction (PubMedID 27578003)
0

Data Source:
BioGRID (pull down)

		COPB2	WBP2
Description		coat protein complex I subunit beta 2	WW domain binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Establishment Of Protein Localization To Chromatin Cellular Response To Estrogen Stimulus
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Kawasaki disease ( 22446961) Male-pattern baldness ( 29146897)	Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)
Interacting Genes		16 interacting genes: ARCN1 COPA CRYAA MCPH1 MFHAS1 MSRA NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L SUMO2 TMED10 WBP2 WEE2-AS1	54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 RUNX1 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2E3 UBE3A UBQLN1 UIMC1 WWC3 WWP1 WWP2 WWTR1 YAP1
Entrez ID		9276	23558
HPRD ID		06103	06097
Ensembl ID		ENSG00000184432	ENSG00000132471
Uniprot IDs		P35606	A6NG10 Q969T9
PDB IDs		8D30 8D41
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Negative Regulation Of Glycine Import Across Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI-coated Vesicle Membrane COPI Vesicle Coat Negative Regulation Of Amino Acid Transport Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Ethanol Negative Regulation Of Transmembrane Transport Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth G-protein Alpha-subunit Binding Response To Amphetamine Negative Regulation Of Organ Growth Negative Regulation Of Transport Positive Regulation Of Heart Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Amine Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Secretion Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cerebellar Purkinje Cell Layer Maturation NF-kappaB P50/p65 Complex Response To Alcohol Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Golgi Vesicle Transport Regulation Of Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Golgi Membrane Body Fluid Secretion Response To Hypoxia Positive Regulation Of Signal Transduction Regulation Of Amine Transport Response To Decreased Oxygen Levels Positive Regulation Of Hyaluronan Biosynthetic Process	COPI Vesicle Coat COPI-coated Vesicle Membrane Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cytosol Protein Ubiquitination Protein Modification By Small Protein Conjugation COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Polyubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Transport Vesicle Protein Monoubiquitination Nucleoplasm Protein K48-linked Ubiquitination Structural Molecule Activity Membrane Coat Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Proteolysis Cytoplasm Potassium Channel Inhibitor Activity Protein K63-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Nephron Tubule Epithelial Cell Differentiation Extracellular Exosome Catabolic Process Protein Tag Activity Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Ubiquitin Protein Ligase Activity Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Proteasomal Protein Catabolic Process Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Protein Catabolic Process Golgi Vesicle Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Histone Ubiquitin Ligase Activity Intracellular Protein Transport Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Cytoplasmic Vesicle Cardiac Muscle Tissue Regeneration Intracellular Protein Localization Negative Regulation Of Cation Transmembrane Transport
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