MAGI1 and LRP2

Number of citations of the paper that reports this interaction (PMID 11274227)
11

Data Source:
HPRD (in vitro, two hybrid)

		MAGI1	LRP2
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs			Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		PR interval ( 23534349)	Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		9223	4036
HPRD ID		04020	02509
Ensembl ID		ENSG00000151276	ENSG00000081479
Uniprot IDs		Q96QZ7	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU	2M0P
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 wes
Tagcloud (Intersection) ?		variants