LRP2 and DLG2

Number of citations: 46 (PubMedID 12713445)
Data Source: BioGRID (two hybrid), HPRD (two hybrid, in vitro)

		LRP2	DLG2
Name		LDL receptor related protein 2	discs large MAGUK scaffold protein 2
Structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome	Cytosol Plasma Membrane Adherens Junction Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Neuromuscular Junction Cell Projection Neuron Projection Perikaryon Juxtaparanode Region Of Axon Synapse Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	GMP Kinase Activity Protein Binding Kinase Binding Protein Kinase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process	Chemical Synaptic Transmission Nervous System Development Protein Localization To Synapse Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Urokinase Insulin human	None
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome	None
GWAS		Anorexia nervosa ( 21079607 ) Blood pressure (smoking interaction) ( 25189868 ) Chronic kidney disease ( 29124443 ) Creatinine levels ( 29124443 29403010 ) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 29403010 27588450 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Gout ( 33832965 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hyperuricemia ( 29124443 ) Macular thickness ( 30535121 ) Optic disc size ( 31809533 ) Proteinuria ( 30476138 ) Proteinuria (mild) ( 30476138 ) Proteinuria (moderate to severe) ( 30476138 ) Relapse in multiple sclerosis ( 28739605 ) Serum creatinine levels ( 29779033 ) Serum uric acid levels ( 30993211 29403010 29124443 ) Urate levels ( 20139978 31578528 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) BMI at adiposity rebound ( 31840077 ) Body fat mass ( 28552196 ) Body mass index ( 28552196 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Chronic obstructive pulmonary disease ( 25584925 ) Chronic periodontitis ( 25008200 ) Estrogen level change in anastrozole-treated breast cancer ( 32701512 ) Familial squamous cell lung carcinoma ( 29924316 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 28552196 ) Influenza A (H1N1) infection ( 26379185 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Lung adenocarcinoma (survival time) in never smokers ( 32699080 ) Migraine without aura ( 28952330 ) Mild influenza (H1N1) infection ( 26379185 ) Modic changes ( 30808802 ) Myopia ( 27182965 ) Nicotine dependence symptom count ( 25555482 ) Obesity-related traits ( 23251661 ) Oily fish consumption ( 32066663 ) Pallidum volume ( 31530798 ) Parkinson's disease ( 32201043 32310270 28892059 28011712 25064009 17052657 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Phospholipid levels (plasma) ( 22359512 ) Pork consumption ( 32066663 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Protein quantitative trait loci ( 18464913 ) Putamen volume ( 29147026 ) Refractive error ( 32231278 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627 ) Schizophrenia ( 30285260 ) Schizophrenia x sex interaction ( 34099189 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical brain region volumes ( 25607358 ) Trunk fat mass ( 28552196 ) Type 2 diabetes ( 31049640 ) Urate levels in overweight individuals ( 25811787 ) Weight ( 28552196 ) Wilms tumor ( 22544364 )
Interacting Genes		53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40	54 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DSCAM ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VANGL2 VTN WNT3A
Entrez ID		4036	1740
HPRD ID		02509	04663
Ensembl ID		ENSG00000081479	ENSG00000150672
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	A0A3B3ISW2 A0A5F9ZH92 A0A994J570 A0A994J587 A0A994J5T6 A0A994J7P1 A0A994J7Q5 A0A994J819 A0A994J822 B5MCC5 B7Z2T4 E9PIJ9 E9PN83 Q15700
PDB IDs		2M0P	2BYG 2HE2
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis	Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Membrane PDZ Domain Binding Regulation Of Membrane Potential Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Chemical Synaptic Transmission Postsynaptic Density Trans-synaptic Signaling Modulation Of Chemical Synaptic Transmission Metal Ion Transport Modulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Glutamate Receptor Signaling Pathway Plasma Membrane Regulation Of System Process Protein Localization To Synapse Monoatomic Ion Transport Dendritic Spine Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Signaling Regulation Of Cell Communication Regulation Of Synapse Organization Protein Localization To Cell Junction Presynapse Assembly Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly Monoatomic Ion Channel Activity Inorganic Ion Transmembrane Transport NMDA Glutamate Receptor Activity Presynapse Organization Regulation Of Nervous System Process Calcium Ion Transport Synaptic Transmission, Glutamatergic