MAGI1 and GBP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		MAGI1	GBP2
Description		membrane associated guanylate kinase, WW and PDZ domain containing 1	guanylate binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Membrane Cell Junction Cell Projection Anchoring Junction Cell Periphery	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Alpha-actinin Binding	Nucleotide Binding GTPase Activity Endopeptidase Inhibitor Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity
	Biological Process	Endothelial Cell Morphogenesis Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Protein-containing Complex Assembly	Activation Of Innate Immune Response Immune System Process Immune Response Protein Localization To Nucleus Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Symbiont Entry Into Host Cell Defense Response To Gram-positive Bacterium Protein Maturation Defense Response To Virus Cytolysis In Another Organism Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways			Interferon gamma signaling Interferon alpha/beta signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 32853455) Cobalt levels ( 26025379) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Cortical surface area (MOSTest) ( 32665545) Crohn's disease-related phenotypes ( 25557950) Declining hemoglobin trajectory in blood donors ( 33491795) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Knee osteoarthritis ( 28916551) Neurociticism ( 29500382) Neuroticism ( 25993607) Nicotine dependence symptom count ( 25555482) Ocular sarcoidosis ( 32141793) Ocular sarcoidosis in sarcoidosis ( 32141793) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 23534349) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tinnitus ( 33742053)	Serum metabolite levels ( 33031748)
Interacting Genes		27 interacting genes: ACTN4 ADGRB1 AMOT ASIC3 ATF6 ATN1 CLCN5 CRHR1 CTNNB1 DAG1 GBP2 IGSF5 IL6R LPP LRP2 NET1 RAC1 RASA1 RASL11B RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		9223	2634
HPRD ID		04020	02682
Ensembl ID		ENSG00000151276	ENSG00000162645
Uniprot IDs		Q96QZ7	P32456 Q8TCE5
PDB IDs		1WBP 2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU 5N7D 5N7F 5N7G 6TWU 6TWX 6TWY 7P71	6VKJ 7E58 7M1S
Enriched GO Terms of Interacting Partners?		Anchoring Junction Ribosomal Protein S6 Kinase Activity Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Stress Fiber Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Developmental Process Engulfment Of Apoptotic Cell Focal Adhesion Bicellular Tight Junction Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Synapse Organization Tube Morphogenesis Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Actin Filament Bundle Assembly TORC1 Signaling Signal Transduction Regulation Of Cellular Component Organization Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Vasculogenesis Animal Organ Development Glutamatergic Synapse Lamellipodium Forebrain Development Cell Junction Regulation Of Signal Transduction Cell-cell Signaling TOR Signaling Gastrulation With Mouth Forming Second Regulation Of Cell-substrate Adhesion Apical Part Of Cell Enzyme Binding Cranial Skeletal System Development Anatomical Structure Arrangement Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Stress Fiber Assembly Cell Communication Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Gliogenesis Blood Vessel Morphogenesis Regulation Of Translation In Response To Stress Cell-matrix Adhesion	Cytoplasm Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Intracellular Signal Transduction Protein Heterodimerization Activity Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Protein Targeting To Mitochondrion Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Microtubule Anchoring At Centrosome Cytoplasmic Translational Initiation Ribonuclease E Activity Spermidine Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Type II Interferon Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Phosphorylation
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