LRP2 and ANKRA2

Number of citations of the paper that reports this interaction (PubMedID 11095640)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		LRP2	ANKRA2
Description		LDL receptor related protein 2	ankyrin repeat family A member 2
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body
Drugs		Urokinase Insulin human
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)	Monobrow thickness ( 26926045)
Interacting Genes		53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40	13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3
Entrez ID		4036	57763
HPRD ID		02509	12044
Ensembl ID		ENSG00000081479	ENSG00000164331
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	Q9H9E1
PDB IDs		2M0P	3SO8 3V2O 3V2X 3V31 4LG6 4QQI 8CXG 8CXH 8CXI
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis	Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity B Cell Differentiation Negative Regulation Of Metabolic Process Protein Kinase C Binding Mononuclear Cell Differentiation Leukocyte Activation Cell Activation Regulation Of Myotube Differentiation Histone Deacetylase Complex Regulation Of Cell Differentiation Leukocyte Differentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Mitochondrial Depolarization B Cell Activation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Lymphocyte Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Negative Regulation Of Long-term Synaptic Potentiation Regulation Of RNA Metabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Striated Muscle Cell Differentiation Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Negative Regulation Of Myotube Differentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Regulation Of Multicellular Organismal Process Response To Catecholamine Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Superoxide Anion Generation SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Superoxide Anion Generation Negative Regulation Of Biosynthetic Process Endosome Lumen Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression
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