LRP2 and ANKRA2

Number of citations of the paper that reports this interaction (PMID 11095640)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		LRP2	ANKRA2
Gene Name		low density lipoprotein receptor-related protein 2	ankyrin repeat, family A (RFXANK-like), 2
Image
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Nucleus Cytosol Cytoskeleton Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	Transcription Cofactor Activity Low-density Lipoprotein Particle Binding Histone Deacetylase Binding
	Biological Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Biological_process
Pathways		Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	10 interactors: ABL1 APP HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX5
Entrez ID		4036	57763
HPRD ID		02509	12044
Ensembl ID		ENSG00000081479	ENSG00000164331
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	Q9H9E1
PDB IDs		2M0P	3SO8 3V2O 3V2X 3V31 4LG6
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation	Regulation Of Skeletal Muscle Fiber Development B Cell Differentiation Cell Activation Histone H4 Deacetylation Regulation Of Muscle Cell Differentiation Histone H3 Deacetylation B Cell Activation Histone H3-K9 Modification Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Skeletal Muscle Tissue Development Lymphocyte Differentiation Histone Deacetylation Protein Deacetylation Peptidyl-lysine Deacetylation Regulation Of Striated Muscle Cell Differentiation Response To Stress Leukocyte Differentiation Signal Transduction Negative Regulation Of Myotube Differentiation Lymphocyte Activation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Coagulation Regulation Of Striated Muscle Tissue Development Signaling Hemostasis Cell Communication Regulation Of Sprouting Angiogenesis Notch Signaling Pathway Regulation Of Protein Binding Cellular Response To Organonitrogen Compound Negative Regulation Of Striated Muscle Cell Differentiation Leukocyte Activation Organ Development Osteoblast Development Regulation Of Cellular Senescence Regulation Of Body Fluid Levels Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Wound Healing Cellular Response To Stimulus Cellular Response To Insulin Stimulus Hemopoiesis Regulation Of Angiogenesis Defense Response Response To Wounding Immune System Development Regulation Of Binding Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation
Tagcloud ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Difference) ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Intersection) ?