MAGI1 and TFAP2A

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		MAGI1	TFAP2A
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Outflow Tract Morphogenesis Keratinocyte Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Transcription From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Embryonic Body Morphogenesis Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Neural Crest Cell Development Anterior Neuropore Closure Trigeminal Nerve Development Oculomotor Nerve Formation Forebrain Neuron Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Embryonic Cranial Skeleton Morphogenesis Epidermis Morphogenesis Palate Development Lens Induction In Camera-type Eye Face Morphogenesis Bone Morphogenesis Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Basement Membrane Organization Metanephric Nephron Development Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS		PR interval ( 23534349)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	30 interactors: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CTNNB1 DEK EP300 EPN2 EPS15 GSTO2 HIP1 LDLRAP1 MAGI1 MKRN3 MYC NPM1 PPARG RB1 SP1 SRA1 SUMO4 SYT1 TP53 UBE2I WWP1 WWP2 YBX1
Entrez ID		9223	7020
HPRD ID		04020	00128
Ensembl ID		ENSG00000151276	ENSG00000137203
Uniprot IDs		Q96QZ7	P05549
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Cell Death Death Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Glial Cell Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Peptidase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Death Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Immune System Development Positive Regulation Of Proteolysis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Intersection) ?