LRP2 and APOB

Number of citations of the paper that reports this interaction (PMID 10330424)
2

Data Source:
HPRD (in vivo, in vitro)

		LRP2	APOB
Gene Name		low density lipoprotein receptor-related protein 2	apolipoprotein B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus
Pathways		Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport	Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs		Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Urate levels ( 20139978)	Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)
Protein-Protein Interactions		48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3
Entrez ID		4036	338
HPRD ID		02509	00133
Ensembl ID		ENSG00000081479	ENSG00000084674
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	P04114 Q59HB3 Q7Z7Q0
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation	Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation
Tagcloud ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Difference) ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Intersection) ?