LRP2 and PIP5K1C

Number of citations of the paper that reports this interaction (PubMedID 10827173)
0

Data Source:
HPRD (two hybrid, in vitro)

		LRP2	PIP5K1C
Description		LDL receptor related protein 2	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome	Phagocytic Cup Uropod Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Endosome Membrane Endomembrane System Membrane Ruffle Membrane Cell Projection Anchoring Junction Presynapse
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Phagocytosis Chemotaxis Cell Adhesion Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs		Urokinase Insulin human
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome	Lethal congenital contractural syndrome (LCCS)
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)
Interacting Genes		53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40	20 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SNCA SRC TLN1 TLN2
Entrez ID		4036	23396
HPRD ID		02509	05834
Ensembl ID		ENSG00000081479	ENSG00000186111
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	O60331
PDB IDs		2M0P	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis	Regulation Of Cellular Localization Positive Regulation Of Transport Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Regulation Of Protein Localization Cell Junction Organization Regulation Of Transport Intracellular Protein Transport Membrane Synaptic Vesicle Endocytosis Intracellular Protein Localization Regulation Of Protein Catabolic Process Presynaptic Endocytosis Plasma Membrane Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Endocytosis Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Organization Protein Localization To Membrane Receptor Internalization Receptor Catabolic Process Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Protein Transport Cell Cortex Phospholipase Binding Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Protein Localization To Plasma Membrane Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Membrane Cellular Component Assembly Intracellular Transport Vesicle-mediated Transport In Synapse Cell Adhesion Import Into Cell Positive Regulation Of Protein Localization To Nucleus Ruffle Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Actin Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Ruffle Extracellular Exosome
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