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LRP2 and DAB2
Number of citations of the paper that reports this interaction (PubMedID
10769163
)
49
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo, two hybrid)
LRP2
DAB2
Description
LDL receptor related protein 2
DAB adaptor protein 2
Image
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Brush Border
Clathrin-coated Pit
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Endocytic Vesicle
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Brush Border Membrane
Endosome Lumen
Cell Projection
Receptor Complex
Apical Part Of Cell
Extracellular Exosome
Fibrillar Center
Cytoplasm
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Clathrin-coated Vesicle
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Molecular Function
Low-density Lipoprotein Particle Receptor Activity
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Insulin-like Growth Factor I Binding
Cargo Receptor Activity
Hormone Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Protein Transporter Activity
Protein Binding
Clathrin Adaptor Activity
Cargo Receptor Activity
SMAD Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Retinoid Metabolic Process
Kidney Development
Neural Tube Closure
Secondary Heart Field Specification
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Ventricular Septum Development
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Nervous System Development
Heart Development
Sensory Perception Of Sound
Cell Population Proliferation
Male Gonad Development
Gene Expression
Protein Transport
Cobalamin Transport
Metal Ion Transport
Negative Regulation Of BMP Signaling Pathway
Forebrain Development
Diol Metabolic Process
Aorta Development
Vitamin D Metabolic Process
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Leptin
Transcytosis
Positive Regulation Of Neurogenesis
Vitamin Transport
Vagina Development
Coronary Vasculature Development
Coronary Artery Morphogenesis
Pulmonary Artery Morphogenesis
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Cellular Response To Growth Factor Stimulus
Amyloid-beta Clearance
Neuron Projection Arborization
Transport Across Blood-brain Barrier
Folate Import Across Plasma Membrane
Cranial Skeletal System Development
Positive Regulation Of Lysosomal Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Endocytosis
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Neuron Projection Development
Protein Transport
Wnt Signaling Pathway
Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Aldosterone Biosynthetic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Leading Edge Cell Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Clathrin Coat Assembly
Response To Steroid Hormone
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Salt
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Aldosterone Secretion
Pathways
Vitamin D (calciferol) metabolism
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Retinoid metabolism and transport
Transport of RCbl within the body
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Urokinase
Insulin human
Diseases
Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS
Anorexia nervosa (
21079607
)
Blood pressure (smoking interaction) (
25189868
)
Chronic kidney disease (
29124443
)
Creatinine levels (
29124443
29403010
)
Estimated glomerular filtration rate (
29779033
31451708
31152163
31015462
30604766
29124443
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (
29403010
27588450
)
Glomerular filtration rate (creatinine) (
26831199
28452372
)
Gout (
33832965
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Hyperuricemia (
29124443
)
Macular thickness (
30535121
)
Optic disc size (
31809533
)
Proteinuria (
30476138
)
Proteinuria (mild) (
30476138
)
Proteinuria (moderate to severe) (
30476138
)
Relapse in multiple sclerosis (
28739605
)
Serum creatinine levels (
29779033
)
Serum uric acid levels (
30993211
29403010
29124443
)
Urate levels (
20139978
31578528
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
33547301
29403010
)
Birth weight (
31043758
)
Chronic kidney disease (
20383146
31152163
)
Creatinine levels (
31015462
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31451708
31152163
30604766
31015462
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
Health literacy (
31250787
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
22158540
)
Premature menopause in childhood cancer survivors (
29432556
)
Self-reported allergy (
23817569
)
Systemic lupus erythematosus (
19838195
)
Urate levels (
23263486
)
Waist-hip ratio (
28552196
)
Interacting Genes
53 interacting genes:
ALB
ANAPC10
ANKRA2
ANKS1B
APBA2
APBB1
APOB
APOE
APOH
APP
ATN1
CDC42
CLU
CUBN
DAB1
DAB2
DLG1
DLG2
DLG3
DLG4
DYRK1A
GC
GIPC1
GPRASP1
INS
ITGB1BP1
LCN2
LDLRAP1
LPA
LPL
LRP2BP
LRPAP1
MAGI1
MAPK8IP1
MAPK8IP2
MDK
NOS1AP
PIP5K1C
PLAU
RAC1
RBP1
RHOA
SCGB1A1
SCN3A
SERPINE1
SLC9A3
SNX17
SYNJ2BP
TG
THBS1
TLN1
TTR
USP40
40 interacting genes:
AP2M1
APLP1
APLP2
APP
ATXN1L
AXIN1
CDC16
CDK1
CSK
DAB2IP
DIP2A
DVL1
DVL3
FCHO1
FCHO2
FGR
GRB2
INPP5D
ITGB3
ITGB5
ITSN1
LDLR
LRP1
LRP2
LRP8
MIB1
MYO6
NECAP1
PIN1
PRKCB
PRKCD
PRKCG
SGIP1
SMAD2
SMAD3
SMURF2
SRC
SUMO2
TGFBR1
TGFBR2
Entrez ID
4036
1601
HPRD ID
02509
03139
Ensembl ID
ENSG00000081479
ENSG00000153071
Uniprot IDs
P98164
Q7Z5C0
Q7Z5C1
B2RAW0
P98082
PDB IDs
2M0P
2LSW
6O5O
6OVF
Enriched GO Terms of Interacting Partners
?
Low-density Lipoprotein Particle Receptor Binding
Regulation Of Endocytosis
Heparin Binding
Regulation Of Cell-substrate Adhesion
Very-low-density Lipoprotein Particle
Regulation Of Receptor-mediated Endocytosis
Amyloid-beta Binding
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Biological Quality
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Vesicle-mediated Transport
Protein Kinase Binding
Negative Regulation Of Fibrinolysis
Regulation Of Locomotion
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Chylomicron
Regulation Of Cell Migration
Positive Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Signal Transduction
Negative Regulation Of Endothelial Cell Migration
Regulation Of Cellular Component Organization
Regulation Of Cell Motility
Regulation Of Cell-matrix Adhesion
Regulation Of Cell Projection Organization
Receptor Ligand Activity
Intermediate-density Lipoprotein Particle
Regulation Of Endothelial Cell Migration
Positive Regulation Of Amyloid Fibril Formation
Negative Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Regulation Of Fibrinolysis
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion
Extracellular Exosome
Positive Regulation Of Cell Motility
Positive Regulation Of Transport
Regulation Of Amyloid-beta Clearance
Regulation Of Proteolysis
Extracellular Region
Regulation Of Transport
Regulation Of Neurofibrillary Tangle Assembly
Positive Regulation Of Locomotion
Positive Regulation Of Cellular Component Organization
Endosome Lumen
Cell Periphery
Cell Adhesion
Positive Regulation Of Receptor-mediated Endocytosis
Clathrin-coated Pit
Endocytosis
Import Into Cell
Plasma Membrane
Cell Surface Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Receptor Complex
Signal Transduction
Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Receptor-mediated Endocytosis
Vesicle-mediated Transport
Regulation Of Cellular Component Organization
Intracellular Signal Transduction
Regulation Of Protein Catabolic Process
Regulation Of Signaling
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Developmental Process
Response To Growth Factor
Regulation Of Cell Communication
Clathrin-dependent Endocytosis
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Tube Morphogenesis
Positive Regulation Of Protein Catabolic Process
Regulation Of Transport
Low-density Lipoprotein Particle Receptor Activity
Membrane
I-SMAD Binding
Cellular Response To Oxygen-containing Compound
Presynaptic Endocytosis
Regulation Of Cellular Response To Growth Factor Stimulus
Vesicle-mediated Transport In Synapse
Regulation Of Protein Localization
Immune Response-activating Cell Surface Receptor Signaling Pathway
SMAD Binding
Cytosol
Positive Regulation Of Lysosomal Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Neuron Projection Morphogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Cell Projection Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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