LRP2 and LPL

Number of citations: 0 (PubMedID 7686151)
Data Source: HPRD (in vitro)

		LRP2	LPL
Name		LDL receptor related protein 2	lipoprotein lipase
Structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Very-low-density Lipoprotein Particle Chylomicron Catalytic Complex
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	Lipoprotein Lipase Activity Phospholipase Activity Triacylglycerol Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-membrane Adaptor Activity Metal Ion Binding Carboxylic Ester Hydrolase Activity Lipoprotein Particle Binding
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process	Retinoid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cellular Response To Nutrient Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Inflammatory Response Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Urokinase Insulin human	Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome	Hyperlipoproteinemia, type I
GWAS		Anorexia nervosa ( 21079607 ) Blood pressure (smoking interaction) ( 25189868 ) Chronic kidney disease ( 29124443 ) Creatinine levels ( 29124443 29403010 ) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 29403010 27588450 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Gout ( 33832965 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hyperuricemia ( 29124443 ) Macular thickness ( 30535121 ) Optic disc size ( 31809533 ) Proteinuria ( 30476138 ) Proteinuria (mild) ( 30476138 ) Proteinuria (moderate to severe) ( 30476138 ) Relapse in multiple sclerosis ( 28739605 ) Serum creatinine levels ( 29779033 ) Serum uric acid levels ( 30993211 29403010 29124443 ) Urate levels ( 20139978 31578528 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Body mass index (adult) ( 28430825 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cardiovascular disease risk factors ( 21943158 ) Cholesterol ( 31902109 ) Cholesterol efflux capacity ( 30369316 ) Coronary artery disease ( 24262325 29212778 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diffusing capacity of carbon monoxide ( 30694715 ) Eosinophil count ( 32888494 ) Fasting triglyceride levels ( 32603185 ) Gut microbiota (beta diversity) ( 27723756 ) HDL cholesterol ( 18193043 18193044 19060906 19060911 20031538 20686565 20864672 21347282 21909109 23726366 24097068 24507774 25961943 26160806 26582766 26780889 28270201 ) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085 ) HDL cholesterol levels ( 26763881 28334899 30698716 31694877 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) HDL levels x fish oil supplementation interaction (2df) ( 33760818 ) Hematological and biochemical traits ( 20139978 ) High density lipoprotein cholesterol levels ( 28548082 29403010 29615537 30718733 30911093 32902719 33339817 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hyperactive-impulsive symptoms ( 18821565 ) Hypertriglyceridemia ( 20657596 23505323 ) Lipid metabolism phenotypes ( 19936222 22286219 ) Lipid traits ( 24023261 24386095 ) Lipoprotein (a) levels ( 33730874 ) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643 ) Low density lipoprotein cholesterol levels ( 32154731 32902719 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (antithrombotic agents) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 20694148 21386085 22399527 30382898 31589552 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Metabolic traits ( 19060910 ) Metabolically unhealthy in normal weight ( 33500527 ) Metabolically unhealthy in obesity ( 33500527 ) Metabolite levels ( 22916037 ) Myocardial infarction ( 33532862 ) Non-HDL cholesterol levels ( 32902719 ) Nonalcoholic fatty liver disease ( 34841290 ) Peripheral artery disease ( 31285632 ) Persistent hepatitis B virus infection ( 27244555 ) Platelet distribution width ( 32888494 ) Postprandial triglyceride levels ( 32603185 ) Pulse pressure ( 27841878 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels ( 32902719 ) Total triglycerides levels ( 26690388 29084231 ) Triacylglyceride levels ( 31551469 ) Triglyceride levels ( 26763881 28334899 29403010 29615537 30698716 30718733 30911093 32154731 32203549 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels in HIV infection ( 33109212 ) Triglyceride levels in small VLDL ( 29084231 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglyceride to HDL cholesterol ratio ( 28046027 ) Triglycerides ( 17463246 18193043 18193044 18193046 19060906 19060911 20139978 20686565 20864672 21909109 22171074 23726366 24097068 24507774 24886709 25961943 26160806 26582766 ) Triglycerides-Blood Pressure (TG-BP) ( 21386085 ) Type 2 diabetes ( 29632382 30054458 30297969 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Waist circumference and related phenotypes ( 18454146 )
Novel Interactors		6 novel interactors: COL3A1 EIPR1 GALNT3 HK3 TANK TBR1	None recorded
Interacting Genes		53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40	18 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 NEIL3 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR
Entrez ID		4036	4023
HPRD ID		02509	01999
Ensembl ID		ENSG00000081479	ENSG00000175445
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	A0A1B1RVA9 P06858
PDB IDs		2M0P	6E7K 6OAU 6OAZ 6OB0 6WN4
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis	Apolipoprotein Binding Clathrin-coated Pit Low-density Lipoprotein Particle Receptor Activity Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Cargo Receptor Activity Astrocyte Activation Involved In Immune Response Intermediate-density Lipoprotein Particle Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Receptor Complex Regulation Of Lysosomal Protein Catabolic Process Low-density Lipoprotein Particle Hormone Binding Reverse Cholesterol Transport Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Response To Leptin Transcytosis Regulation Of Amyloid-beta Clearance Endosome Lumen Regulation Of Endocytosis Molecular Function Activator Activity Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Lipid Transport Amyloid Fibril Formation Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Endocytosis Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Negative Regulation Of Wnt Signaling Pathway Receptor-mediated Endocytosis Triglyceride Homeostasis Acylglycerol Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Regulation Of Cholesterol Efflux TMEM240-body Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity