LRP2 and SLC9A3

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		LRP2	SLC9A3
Description		LDL receptor related protein 2	solute carrier family 9 member A3
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome	Endosome Early Endosome Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Sodium/Proton exchangers
Drugs		Urokinase Insulin human	Tenapanor
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 23128233 28067908)
Interacting Genes		53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40	9 interacting genes: CHP1 CHP2 LRP2 MAST2 NEDD4L NHERF1 NHERF2 PDZK1 SHANK2
Entrez ID		4036	6550
HPRD ID		02509	01660
Ensembl ID		ENSG00000081479	ENSG00000066230
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	P48764
PDB IDs		2M0P	7X2U
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis	Brush Border Membrane Apical Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Plasma Membrane Phosphatase Binding Regulation Of Sodium Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Regulation Of Dephosphorylation Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Sodium Ion Transport Protein Localization To Plasma Membrane Regulation Of Protein Targeting To Membrane Intracellular Protein Localization Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Sodium Ion Transmembrane Transport Transmembrane Transport Metal Ion Transport Protein Localization To Cell Periphery Extracellular Exosome Endomembrane System Brush Border Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Monoatomic Cation Transport Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Regulation Of Metal Ion Transport Transport Across Blood-brain Barrier PDZ Domain Binding Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Apical Part Of Cell Regulation Of Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Monoatomic Ion Transport Regulation Of Protein Localization Signaling Receptor Binding Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Beta-catenin Binding Membrane Folate Transmembrane Transport
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