LRP2 and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (two hybrid, in vitro)

		LRP2	MAPK8IP2
Gene Name		low density lipoprotein receptor-related protein 2	mitogen-activated protein kinase 8 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		4036	23542
HPRD ID		02509	09674
Ensembl ID		ENSG00000081479	ENSG00000008735
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	Q13387
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
Tagcloud ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?