MAGI1 and CLCN5

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		MAGI1	CLCN5
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	chloride channel, voltage-sensitive 5
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Golgi Membrane Lysosomal Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity ATP Binding Antiporter Activity
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Transport Endocytosis Excretion Ion Transmembrane Transport Regulation Of Anion Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways			Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		PR interval ( 23534349)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	4 interactors: CFL1 MAGI1 WWP1 WWP2
Entrez ID		9223	1184
HPRD ID		04020	02053
Ensembl ID		ENSG00000151276	ENSG00000171365
Uniprot IDs		Q96QZ7	A8K4H5 B3KRR2 P51795
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU	2J9L 2JA3
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Viral Entry Into Host Cell Entry Into Host Cell Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Viral Life Cycle Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Cell Size Neural Fold Formation Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Positive Regulation Of Protein Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Potassium Ion Transmembrane Transporter Activity Morphogenesis Of An Epithelial Fold Protein K63-linked Ubiquitination Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Transmembrane Transport Mitotic Cytokinesis Negative Regulation Of Transporter Activity Protein Autoubiquitination Cellular Macromolecule Catabolic Process Neural Crest Cell Migration Regulation Of Dendritic Spine Development Cellular Protein Modification Process Negative Regulation Of ERK1 And ERK2 Cascade
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy
Tagcloud (Intersection) ?