MAGI1 and ACTN4

Number of citations of the paper that reports this interaction (PMID 12042308)
23

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MAGI1	ACTN4
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	actinin, alpha 4
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways			Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		PR interval ( 23534349)	Heart rate ( 23583979)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		9223	81
HPRD ID		04020	05222
Ensembl ID		ENSG00000151276
Uniprot IDs		Q96QZ7	O43707
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU	1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?