MAGI1 and NET1

Number of citations of the paper that reports this interaction (PMID 11350080)
9

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAGI1	NET1
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 1	neuroepithelial cell transforming 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Cell Junction Cell Projection	Nucleus Cytosol Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Protein Complex Scaffold Alpha-actinin Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTP-Rho Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Cell Surface Receptor Signaling Pathway Neuron Death	Regulation Of Cell Growth Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Myoblast Migration Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		PR interval ( 23534349)
Protein-Protein Interactions		23 interactors: ACTN4 AMOT ASIC3 ATN1 BAI1 CLCN5 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	2 interactors: MAGI1 RHOA
Entrez ID		9223	10276
HPRD ID		04020	07342
Ensembl ID		ENSG00000151276	ENSG00000173848
Uniprot IDs		Q96QZ7	Q5SQI5 Q5SQI7 Q7Z628
PDB IDs		2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU	3EO2
Enriched GO Terms of Interacting Partners?		Locomotion Response To External Stimulus Nervous System Development Movement Of Cell Or Subcellular Component Chemotaxis Apoptotic Process Cell Morphogenesis Involved In Differentiation Programmed Cell Death Cell Death Death Axonogenesis Neuron Differentiation System Development Regulation Of Cellular Component Organization Generation Of Neurons Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurogenesis Axon Guidance Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Multicellular Organismal Development Regulation Of Cellular Process Cell Morphogenesis Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Cellular Response To Stimulus Regulation Of Cell Death Neuron Projection Development Cell Projection Morphogenesis Signal Transduction Cell Part Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Cellular Component Movement Response To Growth Factor Developmental Process Toll-like Receptor 5 Signaling Pathway Response To Stimulus Toll-like Receptor 10 Signaling Pathway Cell Development Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Central Nervous System Development Toll-like Receptor 2 Signaling Pathway	Skeletal Muscle Satellite Cell Migration Apolipoprotein A-I-mediated Signaling Pathway Cleavage Furrow Formation Positive Regulation Of Transport Ossification Involved In Bone Maturation Bone Maturation Negative Chemotaxis Mitotic Spindle Assembly Positive Regulation Of NF-kappaB Import Into Nucleus Protein Complex Assembly Regulation Of Osteoblast Proliferation Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Sodium Ion Transport Substantia Nigra Development Wound Healing, Spreading Of Cells Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Cytokinesis Regulation Of NF-kappaB Import Into Nucleus Mitotic Spindle Organization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Trabecula Morphogenesis Neural Nucleus Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Cytokinesis Rho Protein Signal Transduction Morphogenesis Of An Epithelial Sheet Negative Regulation Of Axonogenesis Regulation Of Stress Fiber Assembly Neuron Death Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Axonogenesis Cellular Component Assembly Spindle Assembly Midbrain Development Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Ephrin Receptor Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Cell-cell Junction Assembly Negative Regulation Of Neuron Projection Development Spindle Organization Positive Regulation Of Cell Division
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	alleviation bivalent cdc14 condensin copurified csm1 demethylase demethylates distinctly fork hypercondensed jarid1 jhd2 lrs4 lys36 lys4 lys79 mislocalized nts nts1 nucleolar periphery rdna rent rfb silencing sir2 telophase tof2
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel clca2 complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 manifestations nodosum pcombined phenotypes replicated structuring variants	alleviation bivalent cdc14 condensin copurified csm1 demethylase demethylates distinctly fork hypercondensed jarid1 jhd2 lrs4 lys36 lys4 lys79 mislocalized nts nts1 nucleolar periphery rdna rent rfb silencing sir2 telophase tof2
Tagcloud (Intersection) ?