LRP2 and SCGB1A1

Number of citations of the paper that reports this interaction (PMID 11278724)
9

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LRP2	SCGB1A1
Gene Name		low density lipoprotein receptor-related protein 2	secretoglobin, family 1A, member 1 (uteroglobin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Extracellular Space Nuclear Envelope Rough Endoplasmic Reticulum Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	Protein Binding Phospholipase A2 Inhibitor Activity
	Biological Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine Negative Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Catalytic Activity Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor
Pathways		Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Urate levels ( 20139978)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	5 interactors: CUBN FN1 LMBR1L LRP2 TRIM32
Entrez ID		4036	7356
HPRD ID		02509	01884
Ensembl ID		ENSG00000081479	ENSG00000149021
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	P11684
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation	Vitamin D Metabolic Process Vesicle-mediated Transport Endocytosis Vitamin Metabolic Process Positive Regulation Of Cell Growth Calcium-independent Cell-matrix Adhesion Positive Regulation Of Growth Steroid Metabolic Process Cobalamin Transport Positive Regulation Of Proteolysis Positive Regulation Of Neuron Differentiation Response To Light Stimulus Alcohol Metabolic Process Regulation Of Cell Growth Receptor-mediated Endocytosis Integrin Activation Positive Regulation Of Neurogenesis Negative Regulation Of Viral Release From Host Cell Response To Radiation Cobalamin Metabolic Process Lipoprotein Transport Positive Regulation Of Cell Development Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Neuron Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero
Tagcloud (Difference) ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero
Tagcloud (Intersection) ?