LRP2 and SCN3A

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
BioGRID (two hybrid)

		LRP2	SCN3A
Gene Name		low density lipoprotein receptor-related protein 2	sodium channel, voltage gated, type III alpha subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	Voltage-gated Sodium Channel Activity
	Biological Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	4 interactors: LRP1 LRP2 LRP8 PRKCG
Entrez ID		4036	6328
HPRD ID		02509	01671
Ensembl ID		ENSG00000081479	ENSG00000153253
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	Q9C007 Q9NY46
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?		Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation	Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Response To Light Stimulus Receptor-mediated Endocytosis Response To Radiation Detection Of Stimulus Regulation Of Phospholipase Activity Endocytosis Positive Regulation Of Mismatch Repair Ammon Gyrus Development Beta-amyloid Clearance Cellular Lipid Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mismatch Repair Response To Abiotic Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Neuron Apoptotic Process Lipid Metabolic Process Steroid Metabolic Process Regulation Of Neuron Death Vesicle-mediated Transport System Development Reelin-mediated Signaling Pathway Alcohol Metabolic Process Multicellular Organismal Development Response To External Stimulus Blood Coagulation Anatomical Structure Development Hemostasis Regulation Of Phospholipase A2 Activity Forebrain Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Chemosensory Behavior Vitamin D Metabolic Process Signal Transduction Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cholesterol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Developmental Process Protein Metabolic Process Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux
Tagcloud ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular
Tagcloud (Difference) ?		adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes	arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular
Tagcloud (Intersection) ?