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LRP2 and INS
Number of citations of the paper that reports this interaction (PubMedID
9773776
)
0
Data Source:
HPRD
(in vitro)
LRP2
INS
Description
LDL receptor related protein 2
insulin
Image
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Brush Border
Clathrin-coated Pit
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Endocytic Vesicle
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Brush Border Membrane
Endosome Lumen
Cell Projection
Receptor Complex
Apical Part Of Cell
Extracellular Exosome
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Transport Vesicle
Endosome Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Secretory Granule Lumen
Molecular Function
Low-density Lipoprotein Particle Receptor Activity
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Insulin-like Growth Factor I Binding
Cargo Receptor Activity
Hormone Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Protein Transporter Activity
Protease Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Hormone Activity
Protein Binding
Identical Protein Binding
Receptor Ligand Activity
Biological Process
Retinoid Metabolic Process
Kidney Development
Neural Tube Closure
Secondary Heart Field Specification
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Ventricular Septum Development
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Nervous System Development
Heart Development
Sensory Perception Of Sound
Cell Population Proliferation
Male Gonad Development
Gene Expression
Protein Transport
Cobalamin Transport
Metal Ion Transport
Negative Regulation Of BMP Signaling Pathway
Forebrain Development
Diol Metabolic Process
Aorta Development
Vitamin D Metabolic Process
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Leptin
Transcytosis
Positive Regulation Of Neurogenesis
Vitamin Transport
Vagina Development
Coronary Vasculature Development
Coronary Artery Morphogenesis
Pulmonary Artery Morphogenesis
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Cellular Response To Growth Factor Stimulus
Amyloid-beta Clearance
Neuron Projection Arborization
Transport Across Blood-brain Barrier
Folate Import Across Plasma Membrane
Cranial Skeletal System Development
Positive Regulation Of Lysosomal Protein Catabolic Process
Positive Regulation Of Cytokine Production
Negative Regulation Of Acute Inflammatory Response
Glucose Metabolic Process
Regulation Of DNA-templated Transcription
Acute-phase Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Regulation Of Protein Localization
Nitric Oxide-cGMP-mediated Signaling
TORC1 Signaling
Wound Healing
Negative Regulation Of Protein Catabolic Process
Vasodilation
Glucose Homeostasis
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Translation
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of D-glucose Import
Positive Regulation Of Insulin Receptor Signaling Pathway
Alpha-beta T Cell Activation
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Secretion
Negative Regulation Of Protein Secretion
Positive Regulation Of Protein Secretion
Cognition
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Fatty Acid Homeostasis
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Respiratory Burst
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Long-term Synaptic Potentiation
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Dendritic Spine Maintenance
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Feeding Behavior
Pathways
Vitamin D (calciferol) metabolism
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Retinoid metabolism and transport
Transport of RCbl within the body
Regulation of gene expression in beta cells
Insulin processing
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
Regulation of insulin secretion
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
NPAS4 regulates expression of target genes
Amyloid fiber formation
Drugs
Urokinase
Insulin human
Glisoxepide
Zinc
M-Cresol
Myristic acid
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
Permanent neonatal diabetes mellitus (PNDM)
Type I diabetes mellitus
Maturity onset diabetes of the young (MODY)
GWAS
Anorexia nervosa (
21079607
)
Blood pressure (smoking interaction) (
25189868
)
Chronic kidney disease (
29124443
)
Creatinine levels (
29124443
29403010
)
Estimated glomerular filtration rate (
29779033
31451708
31152163
31015462
30604766
29124443
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (
29403010
27588450
)
Glomerular filtration rate (creatinine) (
26831199
28452372
)
Gout (
33832965
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Hyperuricemia (
29124443
)
Macular thickness (
30535121
)
Optic disc size (
31809533
)
Proteinuria (
30476138
)
Proteinuria (mild) (
30476138
)
Proteinuria (moderate to severe) (
30476138
)
Relapse in multiple sclerosis (
28739605
)
Serum creatinine levels (
29779033
)
Serum uric acid levels (
30993211
29403010
29124443
)
Urate levels (
20139978
31578528
)
Birth weight (
27680694
)
Celiac disease (
23936387
)
Fasting glucose (
34059833
)
Glycated hemoglobin levels (
34059833
)
Latent autoimmune diabetes vs. type 2 diabetes (
30254083
)
Pediatric autoimmune diseases (
26301688
)
Prostate cancer (
19767753
)
Prostate cancer (SNP x SNP interaction) (
22219177
)
Severe autoimmune type 2 diabetes (
34737425
)
Type 1 diabetes (
25751624
21829393
30659077
31152121
32005708
33830302
19430480
17632545
17554260
)
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) (
29310926
)
Type 1 diabetes in high risk HLA genotype individuals (time to event) (
29310926
)
Type 2 diabetes (
30297969
30718926
31049640
31324766
32499647
)
Interacting Genes
53 interacting genes:
ALB
ANAPC10
ANKRA2
ANKS1B
APBA2
APBB1
APOB
APOE
APOH
APP
ATN1
CDC42
CLU
CUBN
DAB1
DAB2
DLG1
DLG2
DLG3
DLG4
DYRK1A
GC
GIPC1
GPRASP1
INS
ITGB1BP1
LCN2
LDLRAP1
LPA
LPL
LRP2BP
LRPAP1
MAGI1
MAPK8IP1
MAPK8IP2
MDK
NOS1AP
PIP5K1C
PLAU
RAC1
RBP1
RHOA
SCGB1A1
SCN3A
SERPINE1
SLC9A3
SNX17
SYNJ2BP
TG
THBS1
TLN1
TTR
USP40
32 interacting genes:
ADAMTSL4
APP
CCN3
CPE
CRYAB
CTSB
CTSD
CTSE
CYSRT1
GCK
HLA-DQA2
HLA-DQB1
HSPA1A
HSPB1
IDE
IGF1R
IGFBP7
INSR
KMT2A
KRTAP1-1
KRTAP1-3
KRTAP10-8
LRP2
MAPK6
NBPF19
NOTCH2NLA
PTEN
RB1
RGS20
SYTL4
TCF4
TXNDC17
Entrez ID
4036
3630
HPRD ID
02509
01455
Ensembl ID
ENSG00000081479
ENSG00000254647
Uniprot IDs
P98164
Q7Z5C0
Q7Z5C1
I3WAC9
P01308
PDB IDs
2M0P
1A7F
1AI0
1AIY
1B9E
1BEN
1EFE
1EV3
1EV6
1EVR
1FU2
1FUB
1G7A
1G7B
1GUJ
1HIQ
1HIS
1HIT
1HLS
1HTV
1HUI
1IOG
1IOH
1J73
1JCA
1JCO
1JK8
1K3M
1KMF
1LKQ
1LPH
1MHI
1MHJ
1MSO
1OS3
1OS4
1Q4V
1QIY
1QIZ
1QJ0
1RWE
1SF1
1SJT
1SJU
1T0C
1T1K
1T1P
1T1Q
1TRZ
1TYL
1TYM
1UZ9
1VKT
1W8P
1XDA
1XGL
1XW7
1ZEG
1ZEH
1ZNJ
2AIY
2C8Q
2C8R
2CEU
2G54
2G56
2H67
2HH4
2HHO
2HIU
2JMN
2JUM
2JUU
2JUV
2JV1
2JZQ
2K91
2K9R
2KJJ
2KJU
2KQP
2KQQ
2KXK
2L1Y
2L1Z
2LGB
2LWZ
2M1D
2M1E
2M2M
2M2N
2M2O
2M2P
2MLI
2MPG
2MPI
2MVC
2MVD
2N2V
2N2W
2N2X
2OLY
2OLZ
2OM0
2OM1
2OMG
2OMH
2OMI
2OMQ
2QIU
2R34
2R35
2R36
2RN5
2VJZ
2VK0
2W44
2WBY
2WC0
2WRU
2WRV
2WRW
2WRX
2WS0
2WS1
2WS4
2WS6
2WS7
3AIY
3BXQ
3E7Y
3E7Z
3EXX
3FQ9
3HYD
3I3Z
3I40
3ILG
3INC
3IR0
3JSD
3KQ6
3P2X
3P33
3Q6E
3ROV
3TT8
3U4N
3UTQ
3UTS
3UTT
3V19
3V1G
3W11
3W12
3W13
3W7Y
3W7Z
3W80
3ZI3
3ZQR
3ZS2
3ZU1
4AIY
4AJX
4AJZ
4AK0
4AKJ
4CXL
4CXN
4CY7
4EFX
4EWW
4EWX
4EWZ
4EX0
4EX1
4EXX
4EY1
4EY9
4EYD
4EYN
4EYP
4F0N
4F0O
4F1A
4F1B
4F1C
4F1D
4F1F
4F1G
4F4T
4F4V
4F51
4F8F
4FG3
4FKA
4GBC
4GBI
4GBK
4GBL
4GBN
4IUZ
4IYD
4IYF
4NIB
4OGA
4P65
4RXW
4UNE
4UNG
4UNH
4WDI
4XC4
4Y19
4Y1A
4Z76
4Z77
4Z78
5AIY
5BOQ
5BPO
5BQQ
5BTS
5C0D
5CJO
5CNY
5CO2
5CO6
5CO9
5E7W
5EMS
5EN9
5ENA
5HPR
5HPU
5HQI
5HRQ
5HYJ
5MAM
5MHD
5MT3
5MT9
5MWQ
5T7R
5UDP
5UOZ
5UQA
5URT
5URU
5USP
5USS
5USV
5UU2
5UU3
5UU4
5VIZ
5WBT
5WDM
5WOB
6B3Q
6B70
6BFC
6CE7
6CE9
6CEB
6CK2
6GNQ
6GV0
6H3M
6HN5
6JK8
6JR3
6K59
6NWV
6O17
6P4Z
6S34
6S4I
6S4J
6SOF
6TC2
6TYH
6U46
6VEP
6VER
6VES
6VET
6X4X
6Z7W
6Z7Y
7BW7
7BW8
7BWA
7JP3
7KD6
7MD4
7MD5
7MQO
7MQR
7MQS
7NHU
7NMG
7PG0
7PG2
7PG3
7PG4
7QAC
7QGF
7QID
7RKD
7RZE
7RZF
7RZI
7S4Y
7SL1
7SL2
7SL3
7SL4
7SL6
7SL7
7STH
7STI
7STJ
7STK
7U6E
7V3P
7YQ3
7YQ4
7YQ5
7Z5L
7Z5Q
8EYX
8EYY
8EZ0
8GSG
8GUY
8HGZ
8HSF
8HSK
8IPZ
8OKY
8ONI
8ONK
8ONP
8ONR
8PI4
8PI5
8PI6
8PJH
8RRP
8RVT
8SBD
8VCX
8VDD
8WU0
8Z4B
9LVC
9LVD
9LVE
9LVX
9LVY
9M4X
9M4Y
9M4Z
9M50
9M51
Enriched GO Terms of Interacting Partners
?
Low-density Lipoprotein Particle Receptor Binding
Regulation Of Endocytosis
Heparin Binding
Regulation Of Cell-substrate Adhesion
Very-low-density Lipoprotein Particle
Regulation Of Receptor-mediated Endocytosis
Amyloid-beta Binding
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Biological Quality
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Vesicle-mediated Transport
Protein Kinase Binding
Negative Regulation Of Fibrinolysis
Regulation Of Locomotion
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Chylomicron
Regulation Of Cell Migration
Positive Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Signal Transduction
Negative Regulation Of Endothelial Cell Migration
Regulation Of Cellular Component Organization
Regulation Of Cell Motility
Regulation Of Cell-matrix Adhesion
Regulation Of Cell Projection Organization
Receptor Ligand Activity
Intermediate-density Lipoprotein Particle
Regulation Of Endothelial Cell Migration
Positive Regulation Of Amyloid Fibril Formation
Negative Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Regulation Of Fibrinolysis
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion
Extracellular Exosome
Positive Regulation Of Cell Motility
Positive Regulation Of Transport
Regulation Of Amyloid-beta Clearance
Regulation Of Proteolysis
Extracellular Region
Regulation Of Transport
Regulation Of Neurofibrillary Tangle Assembly
Positive Regulation Of Locomotion
Positive Regulation Of Cellular Component Organization
Endosome Lumen
Cell Periphery
Cell Adhesion
Positive Regulation Of Receptor-mediated Endocytosis
Insulin Binding
Antigen Processing And Presentation Of Peptide Antigen
Amyloid-beta Clearance
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Exogenous Peptide Antigen
Neuron Projection Organization
Antigen Processing And Presentation
Identical Protein Binding
Insulin-like Growth Factor I Binding
Antigen Processing And Presentation Of Exogenous Antigen
Lysosome
Transport Vesicle Membrane
Insulin Metabolic Process
PTB Domain Binding
Endosome Lumen
Insulin Receptor Activity
Regulation Of Growth
Insulin Receptor Signaling Pathway
Protein Refolding
Insulin Catabolic Process
Insulin Receptor Complex
Dendritic Spine Organization
Cellular Response To Hormone Stimulus
Regulation Of Apoptotic Process
Negative Regulation Of Cell Population Proliferation
Extracellular Exosome
Regulation Of Programmed Cell Death
Negative Regulation Of Growth
Signal Transduction
Symbiont Entry Into Host Cell
Postsynapse Organization
Regulation Of Generation Of Precursor Metabolites And Energy
MHC Class II Receptor Activity
Regulation Of Glycolytic Process
Response To Hormone
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Neuronal Synaptic Plasticity
Cellular Response To Growth Factor Stimulus
Insulin-like Growth Factor Binding
Dendritic Spine Maintenance
Regulation Of Cell Communication
Regulation Of Signaling
Biological Process Involved In Interaction With Host
Regulation Of Carbohydrate Catabolic Process
Neuron Projection Maintenance
Neurexin Family Protein Binding
Contractile Muscle Fiber
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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