LRRK2 and PIK3R1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK2	PIK3R1
Description		leucine rich repeat kinase 2	phosphoinositide-3-kinase regulatory subunit 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Microvillus Synaptic Vesicle Membrane Axon Dendrite Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Amphisome Autolysosome Membrane Raft Synapse Phagocytic Vesicle Intracellular Organelle Lumen Extracellular Exosome Endoplasmic Reticulum Exit Site Multivesicular Body, Internal Vesicle Postsynapse Glutamatergic Synapse Caveola Neck Presynaptic Cytosol Ribonucleoprotein Complex Wnt Signalosome	Nucleus Cytoplasm Cis-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Membrane
	Molecular Function	SNARE Binding Nucleotide Binding Magnesium Ion Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Microtubule Binding Tubulin Binding Kinase Activity Transferase Activity Hydrolase Activity Syntaxin-1 Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Small GTPase Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Co-receptor Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Kinase A Binding Protein Serine Kinase Activity Beta-catenin Destruction Complex Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity GTPase Activator Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Kinase Regulator Activity Kinase Activator Activity Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity Phosphatidylinositol Kinase Activity Enzyme-substrate Adaptor Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Protein Import Into Nucleus Endocytosis Autophagy Response To Oxidative Stress Mitochondrion Organization Endoplasmic Reticulum Organization Golgi Organization Lysosome Organization Cell Surface Receptor Signaling Pathway JNK Cascade Rho Protein Signal Transduction Spermatogenesis Neuromuscular Junction Development Intracellular Protein Localization Determination Of Adult Lifespan Cellular Response To Starvation Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Regulation Of Neuron Maturation Vesicle-mediated Transport Negative Regulation Of Macroautophagy Calcium-mediated Signaling Striatum Development Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cell Differentiation Regulation Of Proteolysis Neuron Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Regulation Of SNARE Complex Assembly Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Lysosomal Lumen PH Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Negative Regulation Of Notch Signaling Pathway GTP Metabolic Process Protein Autophosphorylation Intracellular Distribution Of Mitochondria Animal Organ Development Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Mitochondrion Localization Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Protein Localization To Endoplasmic Reticulum Exit Site Cellular Response To Manganese Ion Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Excitatory Postsynaptic Potential Neuron Projection Arborization Regulation Of CAMP/PKA Signal Transduction Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Autophagosome Assembly Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Positive Regulation Of Microglial Cell Activation Cellular Response To Curcumin Wnt Signalosome Assembly Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Regulation Of Reactive Oxygen Species Metabolic Process	Intracellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Transcription By RNA Polymerase II Protein Import Into Nucleus Immune Response Negative Regulation Of Cell Adhesion Signal Transduction Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lamellipodium Assembly Protein Transport Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Regulation Of Toll-like Receptor 4 Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To UV Response To Endoplasmic Reticulum Stress Interleukin-18-mediated Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Phosphatidylinositol Phosphate Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway T Follicular Helper Cell Differentiation Myeloid Leukocyte Migration Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		PTK6 promotes HIF1A stabilization	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Signaling by LTK in cancer Signaling by LTK Co-stimulation by ICOS
Drugs		Fostamatinib	SF1126 Enzastaurin Wortmannin
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 23128233 28067908) Leprosy ( 25642632) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) Parkinson's disease ( 19915576 31660654 28892059 28011712 27182965 25064009 24842889 22438815 21738487 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Alzheimer's disease biomarkers ( 23419831) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Basal cell carcinoma ( 33549134) Birth weight ( 31043758) Body fat percentage and HDL-C (pairwise) ( 33619380) Bone mineral density (hip) ( 26911590) Corneal astigmatism ( 30306274) Crohn's disease ( 32581322) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate (creatinine) ( 28452372 26831199) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip minimal joint space width ( 27701424) Intelligence (MTAG) ( 29326435) Leg fat mass (lean adjusted) ( 32719433) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Menarche (age at onset) ( 23599027) Offspring birth weight ( 31043758) Red cell distribution width ( 32888494 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 32203549 29083408) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		143 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B APEX2 APP ARFGAP1 ARHGEF7 ARK2N AURKB BAG1 BAG2 BAG3 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2	180 interacting genes: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 APPL1 AR ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BLK BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CIP2A CLNK CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGF EGFR ENKUR EPHA2 EPOR ERAS ERBB2 ERBB3 ERBB4 ESR1 EZR FASLG FBXO21 FCGR2A FER FES FGFR1 FLT1 FYN GAB1 GAB2 GAB3 GHR GP1BA GRB2 GSPT1 GTF2H1 HCK HCST HGS HOXA1 HRAS HTT IFNAR1 IGF1R IKZF3 IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KBTBD2 KHDRBS1 KIT LAT LCK LNX2 LRRK2 MAPK8 MAPT MET MME MST1R MYO16 NFKBIA NLRP6 NTRK1 NTRK2 NUP85 NYAP1 NYAP2 PASK PDE4D PDGFB PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PRMT8 PROM1 PSEN1 PSMB5 PTEN PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RASD2 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SQSTM1 SRC SSTR2 STAT3 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TNK2 TNS4 TOM1L1 TRAT1 TRIM25 TSHR TTR TUB TUBA1B TUBG1 TXK TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID		120892	5295
HPRD ID		10613	01381
Ensembl ID		ENSG00000188906	ENSG00000145675
Uniprot IDs		Q17RV3 Q5S007	A0A2X0SFG1 P27986
PDB IDs		2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XAF 6XR4 7LHT 7LHW 7LI3 7LI4 7THY 7THZ 8FO2 8FO7 8FO8 8FO9 8SMC 8TXZ 8TYQ 8TZB 8TZC 8TZE 8TZF 8TZG 8TZH 8U1B 8U7H 8U7L 8U8A 8U8B 8VH4 8VH5 9C61 9C76 9CHO	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 5GJI 5ITD 5M6U 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBT 5UK8 5UKJ 5UL1 5VLR 5XGH 5XGI 5XGJ 6NCT 6PYR 6PYU 7CIO 7LM2 7LQ1 7MYN 7MYO 7PG5 7PG6 7RNS 7TZ7 8AM0 8DCP 8DCX 8DD4 8DD8 8GUB 8H36 8H37 8ILR 8ILS 8ILV 8SBC 8SBJ 8TDU 8TGD 8TS7 8TS8 8TS9 8TSA 8TSB 8TSC 8TSD 8TU6 8V8H 8V8I 8V8J 8V8U 8V8V 8W9A 8W9B
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Binding Cytosol Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Apoptotic Process MAP Kinase Kinase Activity Signal Transduction Cytoplasm Programmed Cell Death Frizzled Binding Cell Death Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Arborization Nucleotide Binding ATP Binding Protein Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Projection Organization Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Developmental Cell Growth JUN Kinase Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Neuron Projection Extension Cellular Response To Topologically Incorrect Protein Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Import Into Nucleus Response To Light Stimulus Regulation Of Protein Modification Process Regulation Of Proteolysis Phosphorylation Response To Radiation Protein Metabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Protein Kinase Activity Regulation Of Immune Response Kinase Activity Positive Regulation Of Multicellular Organismal Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation Immune Response-regulating Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Protein Phosphorylation Receptor Complex Positive Regulation Of MAPK Cascade Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Immune Response Cell Migration Cytokine-mediated Signaling Pathway Protein Autophosphorylation Regulation Of Developmental Process Regulation Of Lymphocyte Activation Positive Regulation Of Cell Migration Activation Of Immune Response
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