LRRK2 and KDM4D

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK2	KDM4D
Description		leucine rich repeat kinase 2	lysine demethylase 4D
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Microvillus Synaptic Vesicle Membrane Axon Dendrite Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Amphisome Autolysosome Membrane Raft Synapse Phagocytic Vesicle Intracellular Organelle Lumen Extracellular Exosome Endoplasmic Reticulum Exit Site Multivesicular Body, Internal Vesicle Postsynapse Glutamatergic Synapse Caveola Neck Presynaptic Cytosol Ribonucleoprotein Complex Wnt Signalosome	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Site Of Double-strand Break Blood Microparticle
	Molecular Function	SNARE Binding Nucleotide Binding Magnesium Ion Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Microtubule Binding Tubulin Binding Kinase Activity Transferase Activity Hydrolase Activity Syntaxin-1 Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Small GTPase Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Co-receptor Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Kinase A Binding Protein Serine Kinase Activity Beta-catenin Destruction Complex Binding	Damaged DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Protein Import Into Nucleus Endocytosis Autophagy Response To Oxidative Stress Mitochondrion Organization Endoplasmic Reticulum Organization Golgi Organization Lysosome Organization Cell Surface Receptor Signaling Pathway JNK Cascade Rho Protein Signal Transduction Spermatogenesis Neuromuscular Junction Development Intracellular Protein Localization Determination Of Adult Lifespan Cellular Response To Starvation Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Regulation Of Neuron Maturation Vesicle-mediated Transport Negative Regulation Of Macroautophagy Calcium-mediated Signaling Striatum Development Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cell Differentiation Regulation Of Proteolysis Neuron Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Regulation Of SNARE Complex Assembly Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Lysosomal Lumen PH Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Negative Regulation Of Notch Signaling Pathway GTP Metabolic Process Protein Autophosphorylation Intracellular Distribution Of Mitochondria Animal Organ Development Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Mitochondrion Localization Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Protein Localization To Endoplasmic Reticulum Exit Site Cellular Response To Manganese Ion Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Excitatory Postsynaptic Potential Neuron Projection Arborization Regulation Of CAMP/PKA Signal Transduction Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Autophagosome Assembly Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Positive Regulation Of Microglial Cell Activation Cellular Response To Curcumin Wnt Signalosome Assembly Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Regulation Of Reactive Oxygen Species Metabolic Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation Chromatin Organization Chromatin Remodeling Inflammatory Response DNA Damage Response Regulation Of Gene Expression Positive Regulation Of Chromatin Binding Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		PTK6 promotes HIF1A stabilization	HDMs demethylate histones
Drugs		Fostamatinib
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 23128233 28067908) Leprosy ( 25642632) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) Parkinson's disease ( 19915576 31660654 28892059 28011712 27182965 25064009 24842889 22438815 21738487 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Diabetic kidney disease ( 26305897)
Interacting Genes		143 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B APEX2 APP ARFGAP1 ARHGEF7 ARK2N AURKB BAG1 BAG2 BAG3 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2	4 interacting genes: CEP76 LRRK2 PPP1CC TP53
Entrez ID		120892	55693
HPRD ID		10613	17169
Ensembl ID		ENSG00000188906	ENSG00000186280
Uniprot IDs		Q17RV3 Q5S007	Q6B0I6
PDB IDs		2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XAF 6XR4 7LHT 7LHW 7LI3 7LI4 7THY 7THZ 8FO2 8FO7 8FO8 8FO9 8SMC 8TXZ 8TYQ 8TZB 8TZC 8TZE 8TZF 8TZG 8TZH 8U1B 8U7H 8U7L 8U8A 8U8B 8VH4 8VH5 9C61 9C76 9CHO	3DXT 3DXU 4D6Q 4D6R 4D6S 4HON 4HOO 5F5A 5F5C 5FP4 5FP7 5FP8 5FP9 5FPA 5FPB 5PH0 5PH1 5PH2 5PH3 5PH4 5PH5 5PH6 5PH7 5PH8 5PH9 5PHA 5PHB 5PHC 5PHD 5PHE 5PHF 5PHG 5PHH 5PHI 5PHJ 5PHK 5PHL 5PHM 5PHN 5PHO 5PHP 5PHQ 5PHR 5PHS 5PHT 5PHU 5PHV 5PHW 5PHX 5PHY 5PHZ 5PI0 5PI1 5PI2 5PI3 5PI4 5PI5 5PI6 5PI7 5PI8 5PI9 5PIA 5PIB 5PIC 5PID 5PIE 5PIF 5PIG 5PIH 5PII 5PIJ 5PIK 5PIL 5PIM 5PIN 5PIO 5PIP 5PIQ 5PIR 5PIS 5PIT 5PIU 5PIV 5PIW 5PIX 5PIY 5PIZ 5PJ0 5PJ1 5PJ2 5PJ3 5PJ4 5PJ5 5PJ6 5PJ7 5PJ8 5PJ9 5PJA 5PJB 5PJC 5PJD 5PJE 5PJF 5PJG 5PJH 5PJI 5PJJ 5PJK 5PJL 5PJM 5PJN 5PJO 5PJP 5PJQ 5PJR 5PJS 5PJT 5PJU 5PJV 5PJW 5PJX 5PJY 5PJZ 5PK0 5PK1 5PK2 5PK3 5PK4 5PK5 5PK6 5PK7 5PK8 5PK9 5PKA 5PKB 5PKC 5PKD 5PKE 5PKF 5PKG 5PKH 5PKI 5PKJ 5PKK 5PKL 5PKM 5PKN 5PKO 5PKP 5PKQ 5PKR 5PKS 5PKT 5PKU 5PKV 5PKW 5PKX 5PKY 5PKZ 5PL0 5PL1 5PL2 5PL3 5PL4 5PL5 5PL6 5PL7 5PL8 5PL9 5PLA 5PLB 5PLC 5PLD 5PLE 5PLF 5PLG 5PLH 5PLI 5PLJ 5PLK 5PLL 5PLM 5PLN 5PLO 5PLP 5PLQ 5PLR 5PLS 5PLT 5PLU 5PLV 5PLW 5PLX 5PLY 5PLZ 5PM0 5PM1 5PM2 5PM3 5PM4 5PM5 5PM6 5PM7 5PM8 5PM9 5PMA 5PMB 5PMC 5PMD 5PME 5PMF 5PMG 5PMH 5PMI 5PMJ 5PMK 5PML 5PMM 5PMN 5PMO 5PMP 5PMQ 5PMR 5PMS 5PMT 5PMU 5PMV 5PMW 5PMX 5PMY 5PMZ 5PN0 5PN1 5PN2 5PN3 5PN4 5PN5 5PN6 5PN7 5PN8 5PN9 5PNA 5PNB 5PNC 5PND 5PNE 5PNF 5PNG 5PNH 5PNI 5PNJ 5PNK 5PNL 5PNM 5PNN 5PNO 5PNP 5PNQ 5PNR 5PNS 5PNU 5PNV 5PNW 6ETE 6ETG 6ETS 6ETT 6ETU 6ETV 6ETW 6F5Q 6F5R 6F5S 6F5T 6H0W 6H0X 6H0Y 6H0Z 6H10 6H11 7DYG 7DYQ 8WUG
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Binding Cytosol Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Apoptotic Process MAP Kinase Kinase Activity Signal Transduction Cytoplasm Programmed Cell Death Frizzled Binding Cell Death Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Arborization Nucleotide Binding ATP Binding Protein Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Projection Organization Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Developmental Cell Growth JUN Kinase Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Neuron Projection Extension Cellular Response To Topologically Incorrect Protein Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Import Into Nucleus Response To Light Stimulus Regulation Of Protein Modification Process Regulation Of Proteolysis Phosphorylation Response To Radiation Protein Metabolic Process	Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Determination Of Adult Lifespan Negative Regulation Of Macroautophagy Regulation Of Glial Cell Proliferation Regulation Of Neuroblast Proliferation Cytoskeleton Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Gliogenesis Regulation Of Circadian Rhythm Negative Regulation Of Helicase Activity Mitochondrial Membrane Organization Negative Regulation Of G1 To G0 Transition Negative Regulation Of Autophagy Regulation Of Mitochondrion Organization Regulation Of Neural Precursor Cell Proliferation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Development Protein-containing Complex Circadian Rhythm Oligodendrocyte Apoptotic Process Import Into Nucleus Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Protein Import Into Nucleus Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Intracellular Signaling Cassette Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Catalytic Activity Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Protein Localization To Nucleus Germ Cell Nucleus Cellular Response To Actinomycin D Cellular Response To Starvation
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