LRRK2 and DVL1

Number of citations of the paper that reports this interaction (PubMedID 19625296)
49

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LRRK2	DVL1
Description		leucine rich repeat kinase 2	dishevelled segment polarity protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Microvillus Synaptic Vesicle Membrane Axon Dendrite Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Amphisome Autolysosome Membrane Raft Synapse Phagocytic Vesicle Intracellular Organelle Lumen Extracellular Exosome Endoplasmic Reticulum Exit Site Multivesicular Body, Internal Vesicle Postsynapse Glutamatergic Synapse Caveola Neck Presynaptic Cytosol Ribonucleoprotein Complex Wnt Signalosome	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome
	Molecular Function	SNARE Binding Nucleotide Binding Magnesium Ion Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Microtubule Binding Tubulin Binding Kinase Activity Transferase Activity Hydrolase Activity Syntaxin-1 Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Small GTPase Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Co-receptor Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Kinase A Binding Protein Serine Kinase Activity Beta-catenin Destruction Complex Binding	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Protein Import Into Nucleus Endocytosis Autophagy Response To Oxidative Stress Mitochondrion Organization Endoplasmic Reticulum Organization Golgi Organization Lysosome Organization Cell Surface Receptor Signaling Pathway JNK Cascade Rho Protein Signal Transduction Spermatogenesis Neuromuscular Junction Development Intracellular Protein Localization Determination Of Adult Lifespan Cellular Response To Starvation Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Regulation Of Neuron Maturation Vesicle-mediated Transport Negative Regulation Of Macroautophagy Calcium-mediated Signaling Striatum Development Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cell Differentiation Regulation Of Proteolysis Neuron Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Regulation Of SNARE Complex Assembly Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Lysosomal Lumen PH Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Negative Regulation Of Notch Signaling Pathway GTP Metabolic Process Protein Autophosphorylation Intracellular Distribution Of Mitochondria Animal Organ Development Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Mitochondrion Localization Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Protein Localization To Endoplasmic Reticulum Exit Site Cellular Response To Manganese Ion Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Excitatory Postsynaptic Potential Neuron Projection Arborization Regulation Of CAMP/PKA Signal Transduction Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Autophagosome Assembly Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Positive Regulation Of Microglial Cell Activation Cellular Response To Curcumin Wnt Signalosome Assembly Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Regulation Of Reactive Oxygen Species Metabolic Process	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		PTK6 promotes HIF1A stabilization	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs		Fostamatinib
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 23128233 28067908) Leprosy ( 25642632) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) Parkinson's disease ( 19915576 31660654 28892059 28011712 27182965 25064009 24842889 22438815 21738487 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)
Interacting Genes		143 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B APEX2 APP ARFGAP1 ARHGEF7 ARK2N AURKB BAG1 BAG2 BAG3 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2	45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2
Entrez ID		120892	1855
HPRD ID		10613	03220
Ensembl ID		ENSG00000188906	ENSG00000107404
Uniprot IDs		Q17RV3 Q5S007	O14640
PDB IDs		2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XAF 6XR4 7LHT 7LHW 7LI3 7LI4 7THY 7THZ 8FO2 8FO7 8FO8 8FO9 8SMC 8TXZ 8TYQ 8TZB 8TZC 8TZE 8TZF 8TZG 8TZH 8U1B 8U7H 8U7L 8U8A 8U8B 8VH4 8VH5 9C61 9C76 9CHO	6LCA 6LCB 6TTK
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Binding Cytosol Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Apoptotic Process MAP Kinase Kinase Activity Signal Transduction Cytoplasm Programmed Cell Death Frizzled Binding Cell Death Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Arborization Nucleotide Binding ATP Binding Protein Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Projection Organization Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Developmental Cell Growth JUN Kinase Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Neuron Projection Extension Cellular Response To Topologically Incorrect Protein Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Import Into Nucleus Response To Light Stimulus Regulation Of Protein Modification Process Regulation Of Proteolysis Phosphorylation Response To Radiation Protein Metabolic Process	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process
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