LRRK2 and RALYL

Number of citations of the paper that reports this interaction (PMID 19001729)
2

Data Source:
BioGRID (two hybrid)

		LRRK2	RALYL
Gene Name		leucine-rich repeat kinase 2	RALY RNA binding protein-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Inclusion Body Axon Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding Glycoprotein Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Tubulin Binding Kinase Activity Rho GTPase Binding Syntaxin-1 Binding Clathrin Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Kinase A Binding	Nucleotide Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Endocytosis Autophagy Response To Oxidative Stress Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Determination Of Adult Lifespan Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Neuron Death Cellular Response To Manganese Ion Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Regulation Of Neuron Death Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 22438815 21738487)
Protein-Protein Interactions		33 interactors: ACTB AKT1 ARFGAP1 ARHGEF7 BAG5 DVL1 DVL2 DVL3 EIF4EBP1 HSPD1 L3MBTL3 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MBP PRKCZ PTPN23 RALYL RIPK2 SH3GL1 SH3GL2 SH3GL3 STK24 STK25 STK3 STRBP TAOK3 TRAF2 TUBA1A	17 interactors: AEBP2 AEN BYSL C20orf27 CCDC85B CEP170P1 EWSR1 FXR2 HNRNPC LMO3 LRRK2 MCRS1 PSMF1 RBM41 THAP1 TSNAX ZNF408
Entrez ID		120892	138046
HPRD ID		10613	11236
Ensembl ID		ENSG00000188906	ENSG00000184672
Uniprot IDs		Q17RV3 Q5S007	B3KSX3 B3KT61 G3V129 Q86SE5
PDB IDs		2ZEJ 3D6T
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Anatomical Structure Development Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Developmental Process Regulation Of Signaling Activation Of Innate Immune Response	Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Peroxidase Activity Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Cellular Response To Dopamine Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Kidney Size Regulation Of Fat Cell Differentiation Cellular Response To Manganese Ion Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Intracellular Distribution Of Mitochondria Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Neuron Maturation Tangential Migration From The Subventricular Zone To The Olfactory Bulb Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Hydrogen Peroxide-induced Cell Death Locomotory Exploration Behavior Regulation Of Mitochondrial Fission Positive Regulation Of Protein Catabolic Process Histone H4-K5 Acetylation
Tagcloud ?		autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Difference) ?		autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Intersection) ?