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LRRK2 and ARHGEF7
Number of citations of the paper that reports this interaction (PMID
21048939
)
11
Data Source:
BioGRID
(enzymatic study)
LRRK2
ARHGEF7
Gene Name
leucine-rich repeat kinase 2
Rho guanine nucleotide exchange factor (GEF) 7
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Synaptic Vesicle
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Membrane Raft
Extracellular Vesicular Exosome
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Molecular Function
SNARE Binding
Glycoprotein Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Tubulin Binding
Kinase Activity
Rho GTPase Binding
Syntaxin-1 Binding
Clathrin Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Endocytosis
Autophagy
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Neuromuscular Junction Development
Determination Of Adult Lifespan
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Regulation Of Neuron Maturation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Neuron Death
Cellular Response To Manganese Ion
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Negative Regulation Of Peroxidase Activity
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Pathways
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Crohn's disease (
18587394
21102463
)
Inflammatory bowel disease (
23128233
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
22438815
21738487
)
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Protein-Protein Interactions
33 interactors:
ACTB
AKT1
ARFGAP1
ARHGEF7
BAG5
DVL1
DVL2
DVL3
EIF4EBP1
HSPD1
L3MBTL3
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MBP
PRKCZ
PTPN23
RALYL
RIPK2
SH3GL1
SH3GL2
SH3GL3
STK24
STK25
STK3
STRBP
TAOK3
TRAF2
TUBA1A
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
Entrez ID
120892
8874
HPRD ID
10613
05688
Ensembl ID
ENSG00000188906
ENSG00000102606
Uniprot IDs
Q17RV3
Q5S007
B7Z6G2
E9PDQ5
Q14155
PDB IDs
2ZEJ
3D6T
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Regulation Of JNK Cascade
Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of JNK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAP Kinase Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Anatomical Structure Development
Signal Transduction By Phosphorylation
Regulation Of Catalytic Activity
Regulation Of MAP Kinase Activity
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Signaling
Regulation Of Intracellular Signal Transduction
Cell Communication
Positive Regulation Of Catalytic Activity
Positive Regulation Of Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Signal Transduction
Cell Death
Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Developmental Process
Regulation Of Signaling
Activation Of Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Tagcloud
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Difference)
?
autosomal
decline
difficulty
dj1
england
g2019s
gait
gu
hoehn
idiopathic
leucine
motor
movement
parkinson
pd
pigd
pink1
postural
prkn
rating
schwab
snca
society
staging
udrs
undefined
unified
updrs
yahr
Tagcloud (Intersection)
?