LRRK2 and MAP1B

Number of citations of the paper that reports this interaction (PMID 21159966)
25

Data Source:
BioGRID (enzymatic study)

		LRRK2	MAP1B
Gene Name		leucine-rich repeat kinase 2	microtubule-associated protein 1B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Inclusion Body Axon Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Cell Junction Dendritic Spine
	Molecular Function	SNARE Binding Glycoprotein Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Tubulin Binding Kinase Activity Rho GTPase Binding Syntaxin-1 Binding Clathrin Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Kinase A Binding	Structural Molecule Activity Protein Binding Microtubule Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Endocytosis Autophagy Response To Oxidative Stress Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Determination Of Adult Lifespan Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Neuron Death Cellular Response To Manganese Ion Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Regulation Of Neuron Death Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity	Microtubule Bundle Formation Cellular Process Dendrite Development Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Establishment Of Monopolar Cell Polarity
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 22438815 21738487)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		33 interactors: ACTB AKT1 ARFGAP1 ARHGEF7 BAG5 DVL1 DVL2 DVL3 EIF4EBP1 HSPD1 L3MBTL3 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MBP PRKCZ PTPN23 RALYL RIPK2 SH3GL1 SH3GL2 SH3GL3 STK24 STK25 STK3 STRBP TAOK3 TRAF2 TUBA1A	27 interactors: ACTB ANP32A ARHGEF11 DYNLL1 EEF1D FOS GABRR1 GABRR2 GAN GSK3B LRRK2 MAG MAGOH MAP1A MAPK8 MARCH5 MINK1 NXF1 NXF2 PAFAH1B1 RASSF1 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2
Entrez ID		120892	4131
HPRD ID		10613	01139
Ensembl ID		ENSG00000188906	ENSG00000131711
Uniprot IDs		Q17RV3 Q5S007	P46821 Q6PJD3 Q86X89
PDB IDs		2ZEJ 3D6T
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Anatomical Structure Development Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Developmental Process Regulation Of Signaling Activation Of Innate Immune Response	Nuclear Export MRNA Export From Nucleus RNA Localization Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus Regulation Of Mitochondrion Organization MRNA Transport RNA Transport Positive Regulation Of Mitochondrion Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoplasmic Transport Negative Regulation Of Neuron Projection Development Substantia Nigra Development Regulation Of Cell Morphogenesis Termination Of RNA Polymerase II Transcription Signaling Cell Communication Cellular Response To Inorganic Substance Negative Regulation Of Cell Projection Organization Regulation Of Neuron Maturation Response To Metal Ion Regulation Of Axonogenesis Negative Regulation Of Cell Development Neural Nucleus Development Negative Regulation Of Protein Binding Synaptic Transmission Positive Regulation Of Programmed Cell Death Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Death Regulation Of Neuron Projection Development Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Immune System Process Cellular Response To Oxidative Stress DNA-templated Transcription, Termination Neurotrophin TRK Receptor Signaling Pathway Regulation Of Mitochondrial Fission MRNA 3'-end Processing Nervous System Development Neurotrophin Signaling Pathway Regulation Of Intracellular Transport MAPK Cascade
Tagcloud ?		autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr	accelerated actin assembly barbed bundles cerevisiae coil coiled coisolated coronin coronins crn1delta crn1p cytoskeleton cytoskeletons dimerization filament filaments homologue linking links microtubule microtubules networks nucleation polymerization requirement saccharomyces stabilize
Tagcloud (Difference) ?		autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr	accelerated actin assembly barbed bundles cerevisiae coil coiled coisolated coronin coronins crn1delta crn1p cytoskeleton cytoskeletons dimerization filament filaments homologue linking links microtubule microtubules networks nucleation polymerization requirement saccharomyces stabilize
Tagcloud (Intersection) ?