PRLR and CSH1

Number of citations of the paper that reports this interaction (PMID 10966654)
13

Data Source:
HPRD (in vitro)

		PRLR	CSH1
Gene Name		prolactin receptor	chorionic somatomammotropin hormone 1 (placental lactogen)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen	Extracellular Region
	Molecular Function	Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Protein Homodimerization Activity Ornithine Decarboxylase Activator Activity Metal Ion Binding	Hormone Activity Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway T Cell Activation Activation Of JAK2 Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Fluoxymesterone
Diseases
GWAS			Height ( 23563607)
Protein-Protein Interactions		18 interactors: CISH CREBBP CSH1 FBXW11 GH1 JAK2 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	6 interactors: PRLR PSMD9 PTPN12 SMAD2 SMAD4 SMAD9
Entrez ID		5618	1442
HPRD ID		01457	08350
Ensembl ID		ENSG00000113494	ENSG00000136488
Uniprot IDs		P16471	A6NFB4 A8K6C2 P01243
PDB IDs		1BP3 2LFG 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF	1Z7C
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Response To Peptide Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Organonitrogen Compound Regulation Of Signal Transduction Response To Hormone Cellular Response To Organic Substance Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Communication Response To Organic Substance Regulation Of Kinase Activity Innate Immune Response Immune System Process Cellular Response To Stimulus Immune Response Regulation Of Body Fluid Levels Wound Healing Defense Response Response To Stimulus Negative Regulation Of JAK-STAT Cascade Regulation Of Cellular Response To Insulin Stimulus Response To Wounding Blood Coagulation Hemostasis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process	Cellular Protein Complex Assembly Urogenital System Development Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Cellular Macromolecular Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Developmental Growth Positive Regulation Of BMP Signaling Pathway Kidney Development Renal System Development Protein Complex Assembly Positive Regulation Of Stem Cell Differentiation Epithelium Development Embryonic Axis Specification Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Somatic Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated BMP Signaling Pathway Growth Endoderm Development Embryonic Pattern Specification Regulation Of BMP Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Organ Growth Positive Regulation Of Gene Expression Cellular Protein Modification Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Palate Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Metabolic Process Axis Specification Tissue Development Tube Development
Tagcloud ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently	anchor autosomes bovine cattle chrnb1 chromosome chromosomes comparative completes conservation cryb1 distributed exception hamster homologue largest loci mapped mapping mpo myl4 nf1 p4hb pl1 reveals segment synteny thra1 true
Tagcloud (Difference) ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently	anchor autosomes bovine cattle chrnb1 chromosome chromosomes comparative completes conservation cryb1 distributed exception hamster homologue largest loci mapped mapping mpo myl4 nf1 p4hb pl1 reveals segment synteny thra1 true
Tagcloud (Intersection) ?