PRLR and GH1

Number of citations of the paper that reports this interaction (PubMedID 9556914)
0

Data Source:
HPRD (in vitro)

		PRLR	GH1
Description		prolactin receptor	growth hormone 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Extracellular Matrix Endosome Lumen Vesicle Growth Hormone Receptor Complex
	Molecular Function	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding	Cytokine Activity Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding Growth Hormone Activity
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis	Positive Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of D-glucose Transmembrane Transport Cytokine-mediated Signaling Pathway Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Bone Maturation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Somatotropin Lonapegsomatropin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Chronotype ( 30696823) DHEAS levels ( 34748635) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)	Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	7 interacting genes: GHR PRLR PSMD9 S100A6 S100P SHC1 TREM2
Entrez ID		5618	2688
HPRD ID		01457	00751
Ensembl ID		ENSG00000113494	ENSG00000259384
Uniprot IDs		P16471	B1A4G6 B1A4G7 P01241
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18	1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Lipid Binding Peptide Hormone Binding Extracellular Region Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine Receptor Activity Response To Bacterium Calcium-dependent Protein Binding Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Growth Hormone Receptor Activity Positive Regulation Of MAPK Cascade Prolactin Receptor Activity Shc-EGFR Complex Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Peptidoglycan Regulation Of Engulfment Of Apoptotic Cell Growth Hormone Receptor Complex Response To Cycloheximide Regulation Of MAPK Cascade Protein Homodimerization Activity Plasma Membrane Hormone-mediated Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Proteasome Regulatory Particle Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Cell Proliferation In Bone Marrow Phospholipid Binding Epidermal Growth Factor Binding Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRKA Receptor Binding Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway
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