PRLR and NEK3

Number of citations of the paper that reports this interaction (PMID 15618286)
15

Data Source:
HPRD (in vivo)

		PRLR	NEK3
Gene Name		prolactin receptor	NIMA-related kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen	Nucleus Cytoplasm Axon
	Molecular Function	Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Protein Homodimerization Activity Ornithine Decarboxylase Activator Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway T Cell Activation Activation Of JAK2 Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development	Protein Phosphorylation Mitotic Nuclear Division Cell Division
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Fluoxymesterone
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CISH CREBBP CSH1 FBXW11 GH1 JAK2 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	6 interactors: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2
Entrez ID		5618	4752
HPRD ID		01457	04954
Ensembl ID		ENSG00000113494	ENSG00000136098
Uniprot IDs		P16471	P51956 Q6ZN64
PDB IDs		1BP3 2LFG 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Response To Peptide Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Organonitrogen Compound Regulation Of Signal Transduction Response To Hormone Cellular Response To Organic Substance Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Communication Response To Organic Substance Regulation Of Kinase Activity Innate Immune Response Immune System Process Cellular Response To Stimulus Immune Response Regulation Of Body Fluid Levels Wound Healing Defense Response Response To Stimulus Negative Regulation Of JAK-STAT Cascade Regulation Of Cellular Response To Insulin Stimulus Response To Wounding Blood Coagulation Hemostasis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Activation Of JAK2 Kinase Activity Immune System Process Prolactin Signaling Pathway Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Phagocytosis Activation Of Janus Kinase Activity Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity T Cell Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Prostate Gland Growth Lymphocyte Activation Fructose 2,6-bisphosphate Metabolic Process Blood Coagulation Positive Regulation Of Catalytic Activity Mammary Gland Epithelial Cell Differentiation Hemostasis Positive Regulation Of Ras GTPase Activity Regulation Of Cell Death Immune Response-regulating Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Leukocyte Activation Positive Regulation Of Kinase Activity Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Mitotic Metaphase Plate Congression NAD Biosynthetic Process
Tagcloud ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently	abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited
Tagcloud (Difference) ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently	abundantly attractive bodies cascades constructed determines eb ebs embryoid escs fragments govern hesm01 hesm02 huge igf1r keep kinases libraries mak makes mark3 nek7 northern pluripotency raf semi undifferentiated unlimited
Tagcloud (Intersection) ?