IL12RB2

Gene Name		interleukin 12 receptor, beta 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Protein Kinase Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-protein Interactions		5 interactors: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3595
HPRD ID		03383
Ensembl ID		ENSG00000081985
Uniprot IDs		B4DGA4 Q99665
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Cytokine Stimulus Response To Interferon-gamma Response To Cytokine Interleukin-12-mediated Signaling Pathway JAK-STAT Cascade Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Organic Substance Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Response To Organic Substance Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1