IL12RB2

Description		interleukin 12 receptor subunit beta 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Coreceptor Activity Protein Kinase Binding Cytokine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Response To Cytokine Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation
Pathways		Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576) Crohn's disease ( 22412388 28067908) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 23128233 28067908) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 20639880 21399635 26394269 19458352) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 28714469 33536424 26502338 19838195) Systemic sclerosis ( 29293537 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3595
HPRD ID		03383
Ensembl ID		ENSG00000081985
Uniprot IDs		A0A8Q3SIX0 B4DGA4 B7ZB60 Q99665
PDB IDs		8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation Interleukin-12 Receptor Binding T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Via STAT Alpha-beta T Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Lymphocyte Activation Involved In Immune Response T Cell Differentiation Leukocyte Activation Involved In Immune Response Response To Cytokine Cell Activation Involved In Immune Response Response To Peptide Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Lymphocyte Differentiation Interleukin-23 Receptor Complex T Cell Activation Mononuclear Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Interleukin-23-mediated Signaling Pathway Leukocyte Differentiation Immune Effector Process Cellular Response To Cytokine Stimulus Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T Cell Proliferation Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Lymphocyte Activation Regulation Of Type II Interferon Production Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of Cell Fate Commitment Leukocyte Activation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation
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