IL12RB2 and IL12RB1

Number of citations: 37 (PubMedID 8943050)
Data Source: HPRD (in vitro, in vivo)

		IL12RB2	IL12RB1
Name		interleukin 12 receptor subunit beta 2	interleukin 12 receptor subunit beta 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Coreceptor Activity Protein Kinase Binding Cytokine Binding	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Response To Cytokine Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Diseases		None	IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Behcet's disease ( 20622878 20622879 ) Blood protein levels ( 30072576 ) Crohn's disease ( 22412388 28067908 ) Crohn's disease or systemic sclerosis ( 32024964 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (thyroid preparations) ( 31015401 ) Primary biliary cholangitis ( 20639880 21399635 26394269 19458352 ) Rheumatoid arthritis ( 32868391 ) Severe malaria ( 29381699 ) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699 ) Systemic lupus erythematosus ( 28714469 33536424 26502338 19838195 ) Systemic sclerosis ( 29293537 31672989 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Type 2 diabetes (age of onset) ( 28060188 ) Ulcerative colitis ( 28067908 )	Mental health study participation (completed survey) ( 31263887 ) Pulmonary function in asthmatics ( 23541324 ) Systemic sclerosis ( 30572963 31672989 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		None recorded	1 novel interactors: BRD4
Interacting Genes		5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4	7 interacting genes: CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3595	3594
HPRD ID		03383	03363
Ensembl ID		ENSG00000081985	ENSG00000096996
Uniprot IDs		A0A8Q3SIX0 B4DGA4 B7ZB60 Q99665	P42701
PDB IDs		8XRP 8YI7	6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7
GO Terms Enriched among Interactors		Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation Interleukin-12 Receptor Binding T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Via STAT Alpha-beta T Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Lymphocyte Activation Involved In Immune Response T Cell Differentiation Leukocyte Activation Involved In Immune Response Response To Cytokine Cell Activation Involved In Immune Response Response To Peptide Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Lymphocyte Differentiation Interleukin-23 Receptor Complex T Cell Activation Mononuclear Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Interleukin-23-mediated Signaling Pathway Leukocyte Differentiation Immune Effector Process Cellular Response To Cytokine Stimulus Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T Cell Proliferation Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Lymphocyte Activation Regulation Of Type II Interferon Production Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of Cell Fate Commitment Leukocyte Activation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation	Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity