IL12RB2 and STAT4

Number of citations of the paper that reports this interaction (PMID 10415122)
6

Data Source:
BioGRID (unspecified method)
HPRD (in vitro)

		IL12RB2	STAT4
Gene Name		interleukin 12 receptor, beta 2	signal transducer and activator of transcription 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Cytokine Receptor Activity Protein Kinase Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production	Transcription, DNA-templated Protein Phosphorylation JAK-STAT Cascade Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 21399635 20639880)	Behcet's disease ( 23001997 23291587) Celiac disease and Rheumatoid arthritis ( 21383967) Hepatocellular carcinoma (hepatitis B virus related) ( 23242368) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Primary biliary cirrhosis ( 23000144 21399635) Rheumatoid arthritis ( 20453841 20453842) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		5 interactors: IL12B IL12RB1 JAK2 SOCS3 STAT4	13 interactors: ADRB2 CREBBP IFNGR1 IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 STAT3 UBC ZNF467
Entrez ID		3595	6775
HPRD ID		03383	02779
Ensembl ID		ENSG00000081985	ENSG00000138378
Uniprot IDs		B4DGA4 Q99665	Q14765
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Cytokine Stimulus Response To Interferon-gamma Response To Cytokine Interleukin-12-mediated Signaling Pathway JAK-STAT Cascade Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Organic Substance Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Response To Organic Substance Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process	Defense Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor Signaling Pathway Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cell Communication RNA Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Activation Of Innate Immune Response Response To Cytokine Cellular Response To Organic Substance Immune Response Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Positive Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Immune Response Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Signaling Cell Surface Receptor Signaling Pathway MAPK Cascade Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Intersection) ?