RBMX and ROBO3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RBMX	ROBO3
Description		RNA binding motif protein X-linked	roundabout guidance receptor 3
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GO Annotations	Cellular Component	Euchromatin Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Membrane Protein-containing Complex Organelle Supraspliceosomal Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Plasma Membrane Membrane Axon
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription By RNA Polymerase II MRNA Processing Membrane Protein Ectodomain Proteolysis RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Homooligomerization Cellular Response To Interleukin-1	Neuron Migration Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Axon Midline Choice Point Recognition Cell Differentiation Tube Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Dendrite Self-avoidance Commissural Neuron Axon Guidance Positive Regulation Of Axon Guidance
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Pediatric autoimmune diseases ( 26301688)	Macular thickness ( 30535121)
Interacting Genes		51 interacting genes: APOBEC3C CCDC33 CEBPA CIRBP CLK1 CLK3 CMTM6 CNNM3 CSNK2A1 FOXP1 FXR2 HNRNPK IL7R ITSN2 JAK2 KHDRBS2 KHDRBS3 LINC01232 LNX1 MAGOHB MYPOP NABP1 NEIL3 NFE2L2 NXF1 NYX OGT PCBP2 PCDHB14 PRPF31 PRR3 PSMF1 PWARSN RAMAC RBM3 RBM7 RBMY1A1 RBMY1E RBMY1F RBMY1J ROBO3 SF1 SNRPA SOCS3 SORBS3 SREK1 SRPK2 STAT5A TRA2B XRN1 ZNF490	9 interacting genes: APP CCDC57 CXCL14 HSF2BP LNX1 MTUS2 NEDD4L PICK1 RBMX
Entrez ID		27316	64221
HPRD ID		02186	10554
Ensembl ID		ENSG00000147274	ENSG00000154134
Uniprot IDs		P38159	Q96MS0
PDB IDs		2MB0 2MKS	6POG 6POK 6POL
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Spliceosomal Complex RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Metabolic Process RNA Processing Positive Regulation Of MRNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Metabolic Process Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Interleukin-6-mediated Signaling Pathway MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Interleukin-5-mediated Signaling Pathway Cytoplasmic Stress Granule Thrombopoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Mammary Gland Epithelium Development Protein Domain Specific Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Proteasomal Protein Catabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT	Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Glial Cell Development Synapse Organization Regulation Of Endocytosis Plasma Membrane Bounded Cell Projection Organization G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Cell Junction Organization Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Supraspliceosomal Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Main Axon Regulation Of Spontaneous Synaptic Transmission
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