RBMX and NEIL3

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		RBMX	NEIL3
Description		RNA binding motif protein X-linked	nei like DNA glycosylase 3
Image
GO Annotations	Cellular Component	Euchromatin Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Membrane Protein-containing Complex Organelle Supraspliceosomal Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription By RNA Polymerase II MRNA Processing Membrane Protein Ectodomain Proteolysis RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Homooligomerization Cellular Response To Interleukin-1	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs
Diseases
GWAS		Pediatric autoimmune diseases ( 26301688)	Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: APOBEC3C CCDC33 CEBPA CIRBP CLK1 CLK3 CMTM6 CNNM3 CSNK2A1 FOXP1 FXR2 HNRNPK IL7R ITSN2 JAK2 KHDRBS2 KHDRBS3 LINC01232 LNX1 MAGOHB MYPOP NABP1 NEIL3 NFE2L2 NXF1 NYX OGT PCBP2 PCDHB14 PRPF31 PRR3 PSMF1 PWARSN RAMAC RBM3 RBM7 RBMY1A1 RBMY1E RBMY1F RBMY1J ROBO3 SF1 SNRPA SOCS3 SORBS3 SREK1 SRPK2 STAT5A TRA2B XRN1 ZNF490	54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B
Entrez ID		27316	55247
HPRD ID		02186	16407
Ensembl ID		ENSG00000147274	ENSG00000109674
Uniprot IDs		P38159	Q8TAT5
PDB IDs		2MB0 2MKS	7JL5 7TMY
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Spliceosomal Complex RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Metabolic Process RNA Processing Positive Regulation Of MRNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Metabolic Process Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Interleukin-6-mediated Signaling Pathway MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Interleukin-5-mediated Signaling Pathway Cytoplasmic Stress Granule Thrombopoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Mammary Gland Epithelium Development Protein Domain Specific Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Proteasomal Protein Catabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT	RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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