ADAM15 and SH3RF1

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vitro)

		ADAM15	SH3RF1
Gene Name		ADAM metallopeptidase domain 15	SH3 domain containing ring finger 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding	Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	18 interactors: ADAM15 AKT1 AKT2 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N
Entrez ID		8751	57630
HPRD ID		05674	15335
Ensembl ID		ENSG00000143537	ENSG00000154447
Uniprot IDs		B4DMH8 Q13444 U3KQL5	Q7Z6J0
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process	Cell Death Death Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Apoptotic Process Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Signaling Regulation Of Catalytic Activity Intracellular Signal Transduction Cell Communication Activation Of JNKK Activity Positive Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Signal Transduction By Phosphorylation Response To Stress Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Stress MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Stimulus Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Signaling Regulation Of Organelle Organization
Tagcloud ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?