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ADAM15 and NPHP1
Number of citations of the paper that reports this interaction (PubMedID
16374509
)
24
Data Source:
HPRD
(in vitro)
ADAM15
NPHP1
Description
ADAM metallopeptidase domain 15
nephrocystin 1
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Adherens Junction
Cilium
Cell Surface
Endomembrane System
Membrane
Cytoplasmic Vesicle
Motile Cilium
Cell Projection
Extracellular Exosome
Anchoring Junction
Cytoplasm
Cytosol
Cytoskeleton
Cell-cell Junction
Adherens Junction
Bicellular Tight Junction
Cilium
Membrane
Motile Cilium
Photoreceptor Connecting Cilium
Cell Projection
Anchoring Junction
Molecular Function
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Hydrolase Activity
SH3 Domain Binding
Immunoglobulin Receptor Binding
Metal Ion Binding
Structural Molecule Activity
Protein Binding
Biological Process
Angiogenesis
Negative Regulation Of Cell-matrix Adhesion
Immune Response To Tumor Cell
Proteolysis
Apoptotic Process
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Male Gonad Development
Extracellular Matrix Disassembly
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Collagen Catabolic Process
Tissue Regeneration
Innate Immune Response
Cardiac Epithelial To Mesenchymal Transition
Negative Regulation Of Receptor Binding
Cellular Response To Phorbol 13-acetate 12-myristate
Response To Hypobaric Hypoxia
Signal Transduction
Spermatogenesis
Visual Behavior
Cell Projection Organization
Actin Cytoskeleton Organization
Cell Differentiation
Spermatid Differentiation
Retina Development In Camera-type Eye
Protein Localization Involved In Establishment Of Planar Polarity
Cell-cell Adhesion
Positive Regulation Of Bicellular Tight Junction Assembly
Pathways
Degradation of the extracellular matrix
Invadopodia formation
Anchoring of the basal body to the plasma membrane
Drugs
Diseases
Joubert syndrome
Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
Senior-Loken syndrome
GWAS
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chin dimples (
27182965
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Eosinophil percentage of white cells (
32888494
)
General risk tolerance (MTAG) (
30643258
)
Hip circumference adjusted for BMI (
34021172
)
Mosquito bite size (
28199695
)
Prostate cancer (
23535732
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Systemic lupus erythematosus (
28714469
)
Walking pace (
33128006
)
Interacting Genes
34 interacting genes:
ABL1
ARHGEF6
ARHGEF7
ATXN1
BANP
FHL3
FYN
GRB2
HCK
LCK
LYN
MAD2L2
NCK1
NPHP1
NUP62
ODAM
PACSIN3
RBPMS
SH3D19
SH3GL2
SH3GLB1
SH3PXD2A
SH3RF1
SH3RF3
SNX30
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SP4
SRC
TRIP13
YES1
16 interacting genes:
ADAM15
ARHGAP32
BCAR1
FBXO7
FLNA
FLNB
FLNC
INVS
KHDRBS1
NPHP3
NPHP4
PAK2
PTK2B
TNK2
TUBB
UBQLN4
Entrez ID
8751
4867
HPRD ID
05674
09524
Ensembl ID
ENSG00000143537
ENSG00000144061
Uniprot IDs
Q13444
B4DQY0
C9JNM7
O15259
PDB IDs
1S1N
6O1Q
Enriched GO Terms of Interacting Partners
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Fc-gamma Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Non-membrane Spanning Protein Tyrosine Kinase Activity
Fc Receptor Mediated Stimulatory Signaling Pathway
Ephrin Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Ephrin Receptor Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
T Cell Costimulation
Regulation Of Cellular Component Organization
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Organization
Cytoplasm
Positive Regulation Of Cellular Component Biogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Organelle Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Tyrosine Kinase Activity
Cytosol
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Positive Regulation Of Organelle Organization
Positive Regulation Of T Cell Activation
Regulation Of MAPK Cascade
Peptidyl-tyrosine Phosphorylation
Regulation Of Lymphocyte Activation
Positive Regulation Of Metabolic Process
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cytoskeleton Organization
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Leukocyte Cell-cell Adhesion
Anchoring Junction
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Proteolysis
Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell-cell Adhesion
Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune Response
Regulation Of Cellular Component Organization
Anchoring Junction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion
Cell Surface Receptor Signaling Pathway
Cytosol
Cell Projection
Cell Cortex
Signal Transduction
Endothelin Receptor Signaling Pathway
Apical Dendrite
Integrin-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Actin Cytoskeleton
SH3 Domain Binding
Developmental Process
Cytoplasm
Regulation Of Apoptotic Process
Cytoskeleton Organization
Immune System Process
Z Disc
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Programmed Cell Death
Actin Cytoskeleton Organization
Neurotransmitter Receptor Regulator Activity
Perinuclear Region Of Cytoplasm
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Actin Filament-based Process
Kidney Development
BIM-BCL-2 Complex
BIM-BCL-xl Complex
Grb2-Sos Complex
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Determination Of Stomach Left/right Asymmetry
Photoreceptor Cell Maintenance
Determination Of Intestine Left/right Asymmetry
Negative Regulation Of Wnt Signaling Pathway
Ciliary Base
Protein Localization To Ciliary Inversin Compartment
Protein Kinase Binding
Actin Filament Binding
Cell-cell Junction
Regulation Of Cell-substrate Adhesion
Cell Adhesion
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Signal Transduction
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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