ADAM15 and SH3RF3

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ADAM15	SH3RF3
Gene Name		ADAM metallopeptidase domain 15	SH3 domain containing ring finger 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding	Protein Binding Zinc Ion Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	3 interactors: ADAM15 PAK2 RAC1
Entrez ID		8751	344558
HPRD ID		05674	19427
Ensembl ID		ENSG00000143537
Uniprot IDs		B4DMH8 Q13444 U3KQL5	Q8TEJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process	Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation T Cell Costimulation Regulation Of Defense Response To Virus Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Cell Morphogenesis Cell-matrix Adhesion Immune Response Defense Response Regulation Of Cell-substrate Adhesion Positive Regulation Of T Cell Activation Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Cell-substrate Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Engulfment Of Apoptotic Cell Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Mast Cell Chemotaxis Cell Development Positive Regulation Of Cell Activation Intracellular Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Immune System Process Axon Guidance Regulation Of Lymphocyte Activation Negative Regulation Of Receptor Binding Tangential Migration From The Subventricular Zone To The Olfactory Bulb Negative Regulation Of Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Olfactory Bulb Interneuron Development Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Respiratory Burst Axonogenesis Auditory Receptor Cell Morphogenesis Viral Process Phagocytosis, Engulfment Positive Regulation Of Transferase Activity
Tagcloud ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?