ADAM15 and SNX33

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vivo, in vitro)

		ADAM15	SNX33
Gene Name		ADAM metallopeptidase domain 15	sorting nexin 33
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome	Endosome Cytosol Membrane Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding	Protein Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Endosome Organization Mitotic Nuclear Division Vesicle Organization Endosomal Transport Protein Import Cleavage Furrow Formation Macropinocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Membrane Tubulation Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	3 interactors: ADAM15 FASLG PAK2
Entrez ID		8751	257364
HPRD ID		05674	11331
Ensembl ID		ENSG00000143537
Uniprot IDs		B4DMH8 Q13444 U3KQL5	Q8WV41
PDB IDs			4AKV
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process	Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Endosomal Lumen Acidification Retinal Cell Programmed Cell Death Cell Development Necroptotic Signaling Pathway Immune System Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Receptor Binding Cellular Chloride Ion Homeostasis Negative Regulation Of Execution Phase Of Apoptosis Inflammatory Cell Apoptotic Process Anatomical Structure Morphogenesis Chloride Ion Homeostasis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Cell Death Regulation Of Cell Adhesion T Cell Apoptotic Process Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Cell Morphogenesis Involved In Differentiation PH Reduction Positive Regulation Of ERBB Signaling Pathway Cell Differentiation Regulation Of Execution Phase Of Apoptosis Regulation Of Defense Response To Virus By Virus Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Necroptotic Process Endosome Organization Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Cell-matrix Adhesion Apoptotic Process Developmental Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organ Morphogenesis Programmed Cell Death System Development Regulation Of Intracellular PH
Tagcloud ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?