ADAM15 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 16374509)
24

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ADAM15	ARHGEF6
Description		ADAM metallopeptidase domain 15	Rac/Cdc42 guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cilium Cell Surface Endomembrane System Membrane Cytoplasmic Vesicle Motile Cilium Cell Projection Extracellular Exosome Anchoring Junction	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Immunoglobulin Receptor Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia	Apoptotic Process JNK Cascade Lamellipodium Assembly
Pathways		Degradation of the extracellular matrix Invadopodia formation	NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Walking pace ( 33128006)	Autism spectrum disorder ( 34069769) Breast cancer ( 29059683)
Interacting Genes		34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		8751	9459
HPRD ID		05674	02226
Ensembl ID		ENSG00000143537	ENSG00000129675
Uniprot IDs		Q13444	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Regulation Of Cellular Component Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Tyrosine Kinase Activity Cytosol Positive Regulation Of Lymphocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of Organelle Organization Positive Regulation Of T Cell Activation Regulation Of MAPK Cascade Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Positive Regulation Of Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell-cell Adhesion Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response	Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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