GPAA1 and GIT1

Data Source: HiPPIP (Novel)

		GPAA1	GIT1
Name		glycosylphosphatidylinositol anchor attachment 1	GIT ArfGAP 1
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding
	Biological Process	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process
Pathways		Attachment of GPI anchor to uPAR	Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
GWAS		Asthma ( 31959851 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 )	Adult body size ( 32376654 ) Brain morphology (MOSTest) ( 32665545 )
Novel Interactors		9 novel interactors: ADAMDEC1 CACNG8 DGAT1 GIT1 LRRC14 LY6E NDRG1 TERF2IP TONSL	2 novel interactors: B9D1 GPAA1
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13	54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		8733	28964
HPRD ID		04334	06577
Ensembl ID		ENSG00000197858	ENSG00000108262
Uniprot IDs		O43292	Q59FC3 Q9Y2X7
PDB IDs		7W72 7WLD 8IMX 8IMY	Not available
GO Terms Enriched among Interactors		GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process	Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization