GPAA1 and TONSL

Data Source: HiPPIP (Novel)

		GPAA1	TONSL
Name		glycosylphosphatidylinositol anchor attachment 1	tonsoku like, DNA repair protein
Structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Cytoplasm Nuclear Body FACT Complex Site Of Double-strand Break MCM Complex Nuclear Replication Fork
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	Protein Binding Histone Binding Histone Reader Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Protein Localization To Chromatin
Pathways		Attachment of GPI anchor to uPAR	None
GWAS		Asthma ( 31959851 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 )	Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		9 novel interactors: ADAMDEC1 CACNG8 DGAT1 GIT1 LRRC14 LY6E NDRG1 TERF2IP TONSL	1 novel interactors: GPAA1
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13	5 interacting genes: CFTR EWSR1 GSK3B MYC PEX14
Entrez ID		8733	4796
HPRD ID		04334	05180
Ensembl ID		ENSG00000197858	ENSG00000160949
Uniprot IDs		O43292	Q96HA7
PDB IDs		7W72 7WLD 8IMX 8IMY	5JA4
GO Terms Enriched among Interactors		GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Microtubule Anchoring At Centrosome Regulation Of Protein Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Peroxisome Transport Along Microtubule Positive Regulation Of Anion Channel Activity Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Myc-Max Complex Regulation Of Acinar Cell Proliferation Cellular Response To Stress Positive Regulation Of Monoatomic Anion Transport NK T Cell Proliferation Protein-containing Complex Disassembly Peroxisomal Importomer Complex GPI-anchor Transamidase Activity Positive Regulation Of Enamel Mineralization Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Cell Cycle Phase Transition Positive Regulation Of B Cell Apoptotic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Protein-containing Complex Transepithelial Water Transport Beta-arrestin-dependent Dopamine Receptor Signaling Pathway GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Cellular Response To Oxygen-containing Compound Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Protein Localization To Cilium Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II