GPAA1 and EIF3E

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GPAA1	EIF3E
Gene Name		glycosylphosphatidylinositol anchor attachment 1	eukaryotic translation initiation factor 3, subunit E
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding Tubulin Binding GPI Anchor Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Protein Complex Assembly C-terminal Protein Lipidation Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein Post-translational Protein Modification Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation
Pathways		Post-translational protein modification Attachment of GPI anchor to uPAR Post-translational modification: synthesis of GPI-anchored proteins	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829)
Protein-Protein Interactions		7 interactors: EIF3E GRIK5 PIGK PIGT PIGU PIN1 PRR13	25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63
Entrez ID		8733	3646
HPRD ID		04334	03734
Ensembl ID		ENSG00000197858	ENSG00000104408
Uniprot IDs		O43292	B3KW56 P60228
PDB IDs
Enriched GO Terms of Interacting Partners?		Attachment Of GPI Anchor To Protein C-terminal Protein Lipidation GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Macromolecule Biosynthetic Process Cellular Lipid Metabolic Process Organophosphate Metabolic Process Protein Retention In ER Lumen Cellular Protein Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Lipid Metabolic Process Biosynthetic Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Protein Modification Process	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging
Tagcloud ?			adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Difference) ?			adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Intersection) ?