GPAA1 and DGAT1

		GPAA1	DGAT1
Description		glycosylphosphatidylinositol anchor attachment 1	diacylglycerol O-acyltransferase 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding Retinol O-fatty-acyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Retinoid Metabolic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Retinol Metabolic Process Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Fatty Acid Homeostasis
Pathways		Attachment of GPI anchor to uPAR	Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)	Dupuytren's disease ( 28886342) Fasting glucose ( 34059833)
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13	3 interacting genes: CCR9 CD1A GABRA4
Entrez ID		8733	8694
HPRD ID		04334	05360
Ensembl ID		ENSG00000197858	ENSG00000185000
Uniprot IDs		O43292	O75907
PDB IDs		7W72 7WLD 8IMX 8IMY	6VP0 6VYI 6VZ1 8ESM 8ETM
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process	Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Exogenous Lipid Antigen Binding Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Endogenous Lipid Antigen Binding GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Protein Retention In ER Lumen Lipopeptide Binding GPI Anchor Binding External Side Of Plasma Membrane Benzodiazepine Receptor Activity Gamma-delta T Cell Differentiation Maintenance Of Protein Localization In Endoplasmic Reticulum GABA-A Receptor Activity GABA-A Receptor Complex GABA-gated Chloride Ion Channel Activity Inhibitory Synapse Assembly Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Activation Antigen Processing And Presentation Of Endogenous Antigen Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dendrite Membrane Synaptic Transmission, GABAergic Positive Regulation Of T Cell Mediated Cytotoxicity Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
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