GPAA1 and GNRHR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPAA1	GNRHR
Description		glycosylphosphatidylinositol anchor attachment 1	gonadotropin releasing hormone receptor
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Plasma Membrane Membrane
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	G Protein-coupled Receptor Activity Gonadotropin-releasing Hormone Receptor Activity Protein-hormone Receptor Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Signal Transduction G Protein-coupled Receptor Signaling Pathway Gonadotropin Secretion Cellular Response To Hormone Stimulus Cellular Response To Gonadotropin-releasing Hormone
Pathways		Attachment of GPI anchor to uPAR	Hormone ligand-binding receptors G alpha (q) signalling events
Drugs			Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix Linzagolix
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13	5 interacting genes: GNRH1 GPAA1 RGS10 TMEM161A TSPAN7
Entrez ID		8733	2798
HPRD ID		04334	00732
Ensembl ID		ENSG00000197858	ENSG00000109163
Uniprot IDs		O43292	P30968
PDB IDs		7W72 7WLD 8IMX 8IMY	7BR3
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process	Response To Prolactin Negative Regulation Of Immature T Cell Proliferation Neurosecretory Vesicle Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Gonadotropin-releasing Hormone Receptor Binding Gonadotropin Hormone-releasing Hormone Activity Regulation Of Ovarian Follicle Development GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen GPI Anchor Binding Estrous Cycle Negative Regulation Of Neuron Migration
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