GPAA1 and GRIK5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GPAA1	GRIK5
Gene Name		glycosylphosphatidylinositol anchor attachment 1	glutamate receptor, ionotropic, kainate 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Endoplasmic Reticulum Plasma Membrane Postsynaptic Density Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding Tubulin Binding GPI Anchor Binding	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Protein Complex Assembly C-terminal Protein Lipidation Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein Post-translational Protein Modification Cellular Protein Metabolic Process	Protein Retention In ER Lumen Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus
Pathways		Post-translational protein modification Attachment of GPI anchor to uPAR Post-translational modification: synthesis of GPI-anchored proteins	Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS			Bipolar disorder ( 21771265)
Protein-Protein Interactions		7 interactors: EIF3E GRIK5 PIGK PIGT PIGU PIN1 PRR13	8 interactors: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		8733	2901
HPRD ID		04334	02614
Ensembl ID		ENSG00000197858	ENSG00000105737
Uniprot IDs		O43292	Q16478
PDB IDs
Enriched GO Terms of Interacting Partners?		Attachment Of GPI Anchor To Protein C-terminal Protein Lipidation GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Macromolecule Biosynthetic Process Cellular Lipid Metabolic Process Organophosphate Metabolic Process Protein Retention In ER Lumen Cellular Protein Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Lipid Metabolic Process Biosynthetic Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Protein Modification Process	Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Membrane Depolarization Negative Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endocytosis Regulation Of Synaptic Transmission Receptor Clustering Cell-cell Signaling Regulation Of Neuronal Synaptic Plasticity Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Endocytosis Positive Regulation Of Synaptic Transmission Cellular Protein Localization Protein Localization To Endoplasmic Reticulum Neuromuscular Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Endocytosis Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Vesicle Organization Maintenance Of Apical/basal Cell Polarity Membrane Organization Regulation Of Cellular Component Organization Receptor Localization To Synapse Regulation Of Neuron Apoptotic Process Negative Regulation Of Receptor Internalization Viral Budding Myeloid Progenitor Cell Differentiation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Neuron Death Synaptic Vesicle Maturation
Tagcloud ?			abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Difference) ?			abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Intersection) ?