GPAA1 and CACNG8

		GPAA1	CACNG8
Description		glycosylphosphatidylinositol anchor attachment 1	calcium voltage-gated channel auxiliary subunit gamma 8
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendrite Membrane Monoatomic Ion Channel Complex Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Channel Regulator Activity Protein Phosphatase 2B Binding Ionotropic Glutamate Receptor Binding
	Biological Process	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Monoatomic Ion Transport Calcium Ion Transport Transmission Of Nerve Impulse Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of AMPA Receptor Activity
Pathways		Attachment of GPI anchor to uPAR	Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions
Drugs			Ergocalciferol Enflurane Spironolactone Nicardipine Verapamil Efonidipine Butamben Bioallethrin
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		8733	59283
HPRD ID		04334	06063
Ensembl ID		ENSG00000197858	ENSG00000142408
Uniprot IDs		O43292	Q8WXS5
PDB IDs		7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process	GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen GPI Anchor Binding Maintenance Of Protein Localization In Endoplasmic Reticulum GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Glycolipid Biosynthetic Process Maintenance Of Location In Cell Maintenance Of Location Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Protein Maturation Glycerolipid Metabolic Process Phospholipid Metabolic Process Carbohydrate Derivative Biosynthetic Process
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