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PLK1 and VMA22
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
PLK1
VMA22
Description
polo like kinase 1
vacuolar ATPase assembly factor VMA22
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome, Centromeric Region
Chromatin
Synaptonemal Complex
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Lysosome
Endosome
Vacuole
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane
Vacuolar Proton-transporting V-type ATPase Complex
COPI-coated Vesicle
Cytoplasmic Vesicle
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Serine Kinase Activity
Protein Binding
Unfolded Protein Binding
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Division
Mitotic Cytokinesis
Double-strand Break Repair Via Homologous Recombination
Microtubule Bundle Formation
Double-strand Break Repair
Protein Phosphorylation
Mitotic Spindle Organization
Sister Chromatid Cohesion
Mitotic Chromosome Condensation
Mitotic Nuclear Membrane Disassembly
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Homologous Chromosome Segregation
Establishment Of Protein Localization
Positive Regulation Of Proteolysis
Golgi Inheritance
Nuclear Membrane Disassembly
Centrosome Separation
Cell Division
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Protein Localization To Centrosome
Protein Localization To Nuclear Envelope
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Intracellular Iron Ion Homeostasis
Lysosomal Lumen Acidification
Cellular Response To Increased Oxygen Levels
Vacuolar Proton-transporting V-type ATPase Complex Assembly
Lysosomal Protein Catabolic Process
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
RHOA GTPase cycle
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Volasertib
Diseases
GWAS
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
147 interacting genes:
-
ACTL6B
AKAP12
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
C6orf136
CBL
CCNB1
CDC14A
CDC25C
CDC6
CEBPA
CENPQ
CENPU
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
CUL4B
DNAJB9
DNHD1
ECT2
EIF6
ERCC6L
EYA1
EYA4
FBXL5
FBXW7
GET4
GLB1
GORASP1
HNRNPU
IDH1
IDH2
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRABD3
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MISP
MPP2
MYC
MYT1
NCAPD3
NCAPG2
NCAPH2
NEDD1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PON1
PPID
PPIL2
PPP1R12A
PPP6R2
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PSRC1
PTEN
PTPRD
RAB1A
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RSF1
RXRA
SEPTIN9
SHCBP1
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STUB1
SUGT1
TIMELESS
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
UBE2I
UHRF1
USP16
USP7
VIM
VMA22
VRK2
VRK3
WAC
WEE1
ZNF71
9 interacting genes:
ABI2
ALOX15B
APP
CSNK2B
MIS18A
NTAQ1
PLK1
PRKCZ
TK1
Entrez ID
5347
84317
HPRD ID
03652
14428
Ensembl ID
ENSG00000166851
ENSG00000136710
Uniprot IDs
P53350
B8ZZ99
Q96NT0
PDB IDs
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
7MSO
7MX1
8BJT
8CRC
8JOQ
8JOY
8S30
8S31
8WFP
8X72
8XB9
Enriched GO Terms of Interacting Partners
?
Proteasome Core Complex
Cell Division
Cytoplasm
Regulation Of Cell Cycle
Nucleoplasm
Regulation Of Cell Cycle Process
Nucleus
Cytosol
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteasome Complex
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Macromolecule Catabolic Process
Positive Regulation Of Cell Cycle
Proteasome Core Complex, Beta-subunit Complex
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle
Spindle
Regulation Of Cell Cycle Phase Transition
Proteasome Core Complex, Alpha-subunit Complex
Regulation Of Cellular Response To Stress
Microtubule-based Process
Organelle Organization
Centrosome
Cytoskeleton
Microtubule Cytoskeleton Organization
Midbody
Proteolysis
Regulation Of Intracellular Signal Transduction
Cellular Response To Radiation
DNA Repair
Chromosome Segregation
Regulation Of Chromosome Organization
Regulation Of Cytokinesis
Macromolecule Metabolic Process
Response To Xenobiotic Stimulus
Regulation Of Organelle Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Chromosome Segregation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cell Cycle
Positive Regulation Of Programmed Cell Death
Protein Kinase Binding
Chromosome
Regulation Of Chromosome Segregation
Phosphate-containing Compound Metabolic Process
Cytosol
Phosphorylation
Protein Phosphorylation
Identical Protein Binding
Nucleus
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Chemokine Production
Endocannabinoid Signaling Pathway
Linoleate 9S-lipoxygenase Activity
Linoleate 13S-lipoxygenase Activity
Anchoring Junction
Cannabinoid Biosynthetic Process
Arachidonate 15-lipoxygenase Activity
Arachidonate 8(S)-lipoxygenase Activity
Lipoxin A4 Biosynthetic Process
Lipoxin Biosynthetic Process
Lipoxin A4 Metabolic Process
Cannabinoid Signaling Pathway
Positive Regulation Of Chemokine Production
Acetylcholine Receptor Activator Activity
Amyloid-beta Complex
PTB Domain Binding
Growth Cone Lamellipodium
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Protein Metabolic Process
Regulation Of Response To Calcium Ion
Amylin Binding
Regulation Of Proteolysis
Endosome To Plasma Membrane Transport Vesicle
Protein Tetramerization
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Regulation Of Protein Catabolic Process
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Modulation Of Excitatory Postsynaptic Potential
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Protein Modification Process
Protein Kinase CK2 Complex
Protein Serine/threonine Kinase Activity
Symbiont-mediated Disruption Of Host Cell PML Body
Protein Localization To Chromosome
Synaptonemal Complex Disassembly
Golgi Inheritance
DNA Synthesis Involved In Mitotic DNA Replication
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Tagcloud (Intersection)
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